Actively Recruiting

Phase 3
Age: 18Years +
All Genders
NCT06707090

Tissue Repair Gel in Venous Leg Ulcers (US)

Led by TR Therapeutics · Updated on 2026-02-12

312

Participants Needed

33

Research Sites

157 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The goal of this clinical trial is to learn if TR987 0.1% gel + Standard of Care works better than Standard of Care alone to treat Venous Leg Ulcers (VLUs). It will also provide additional information about the safety of drug TR987 0.1% gel.

CONDITIONS

Official Title

Tissue Repair Gel in Venous Leg Ulcers (US)

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Adults 18 years and older
  • Clinically diagnosed and medically confirmed venous insufficiency
  • Females who are not pregnant or breastfeeding and use acceptable birth control if of child-bearing potential
  • Venous ulcer size between 2 cm2 and 12 cm2 at randomization
  • Target ulcer age of at least 4 weeks at screening
  • Adequate arterial blood flow confirmed by ABI, TBI, TB, SPP, TCPo2, or Duplex Doppler
  • Body mass index (BMI) of 50 kg/m2 or less
  • HbA1C level of 12% or less
Not Eligible

You will not qualify if you...

  • Target ulcer treated with prohibited medications or therapies
  • History of radiation at the target ulcer site
  • Target ulcer area decreased by 30% or more during screening period
  • History of osteomyelitis at the target ulcer within 6 months before screening
  • Participants considered nutritionally deficient

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 33 locations

1

Clincial Research Site 21

Tucson, Arizona, United States, 85715

Active, Not Recruiting

2

Clincial Research Site 43C

Castro Valley, California, United States, 94546

Actively Recruiting

3

Clincial Research Site 14

Fresno, California, United States, 93710

Actively Recruiting

4

Clincial Research Site 11

Los Angeles, California, United States, 90063

Actively Recruiting

5

Clincial Research Site 43A

San Francisco, California, United States, 94115

Actively Recruiting

6

Clincial Research Site 43B

San Francisco, California, United States, 94117

Actively Recruiting

7

Clincial Research Site 54

Vista, California, United States, 92081

Actively Recruiting

8

Clincial Research Site 47

Deerfield Beach, Florida, United States, 33442

Active, Not Recruiting

9

Clincial Research Site 38

Hollywood, Florida, United States, 33021

Not Yet Recruiting

10

Clincial Research Site 40

Jacksonville, Florida, United States, 32209

Actively Recruiting

11

Clincial Research Site 19

Miami, Florida, United States, 33150

Actively Recruiting

12

Clincial Research Site 26

Miami, Florida, United States, 33156

Actively Recruiting

13

Clincial Research Site 13

Pembrook Pines, Florida, United States, 33026

Actively Recruiting

14

Clincial Research Site 51

Tamarac, Florida, United States, 33321

Withdrawn

15

Clincial Research Site 22

Chicago, Illinois, United States, 60611

Not Yet Recruiting

16

Clincial Research Site 34

Chicago, Illinois, United States, 60649

Actively Recruiting

17

Clincial Research Site 10

O'Fallon, Illinois, United States, 62269

Actively Recruiting

18

Clincial Research Site 49

Springfield, Illinois, United States, 62704

Actively Recruiting

19

Clincial Research Site 04

Bossier City, Louisiana, United States, 71111

Actively Recruiting

20

Clincial Research Site 01

Lafayette, Louisiana, United States, 70507

Actively Recruiting

21

Clincial Research Site 07

D'Iberville, Mississippi, United States, 39540

Actively Recruiting

22

Clincial Research Site 02

McComb, Mississippi, United States, 39648

Actively Recruiting

23

Clincial Research Site 30

New York, New York, United States, 10019

Actively Recruiting

24

Clincial Research Site 37

Syosset, New York, United States, 11791

Actively Recruiting

25

Clincial Research Site 55

Winston-Salem, North Carolina, United States, 27157

Active, Not Recruiting

26

Clincial Research Site 45

Grove City, Ohio, United States, 43123

Withdrawn

27

Clincial Research Site 23

Mentor, Ohio, United States, 44060

Withdrawn

28

Clincial Research Site 28

Tulsa, Oklahoma, United States, 74137

Actively Recruiting

29

Clincial Research Site 36

Philadelphia, Pennsylvania, United States, 19107

Actively Recruiting

30

Clincial Research Site 24

Fort Worth, Texas, United States, 76104

Actively Recruiting

31

Clincial Research Site 32

Houston, Texas, United States, 27707

Actively Recruiting

32

Clincial Research Site 46

San Antonio, Texas, United States, 78224

Not Yet Recruiting

33

Clincial Research Site 18

Suffolk, Virginia, United States, 23434

Actively Recruiting

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Research Team

A

Anhthu Nguyen Vice President, Global Clinical Operations

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

QUADRUPLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

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