Actively Recruiting
Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
Led by Jens Titze · Updated on 2025-06-06
80
Participants Needed
4
Research Sites
139 weeks
Total Duration
On this page
Sponsors
J
Jens Titze
Lead Sponsor
C
Changi General Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study aims to provide quantitative facts on the pathophysiological changes in tissue Na+ content during Na+/K+ redistribution disorders in patients with PA in response to standard therapy. The investigators hypothesize that patients with primary aldosteronism have excessive Na+ storage in the muscle, which can now be quantified non-invasively using 23NaMRI. In analogy to the role of HbA1c as a metabolic long-term marker in diabetes, the quantifiable changes in muscle Na+ content may deliver the data evidence necessary to justify and conduct randomized diagnostic endpoint outcome trials in the future, with the ultimate aim to improve PA detection rate and treatment.
CONDITIONS
Official Title
Tissue Sodium Quantification in Patients With Primary Aldosteronism: See Sodium to Treat
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 21-70 years with arterial hypertension or suspected primary aldosteronism based on guidelines
- Male and female patients older than 21 years
- Willingness to participate and ability to provide informed consent
You will not qualify if you...
- Presence of implanted devices (surgical clips, pacemakers, defibrillators, cochlear implants) or metal not safe for MRI
- Iron-based tattoos
- Noticeable anxiety or claustrophobia related to MRI
- Pregnancy
- Heart failure classified as NYHA III or IV
- Impaired kidney function with eGFR less than 30 ml/min or proteinuria over 1 g/24h
- Liver disease with cirrhosis (Child-Pugh class C) or low albumin levels
- Muscular dystrophies
- Active cancer or severe conditions likely to affect survival or study participation
- Unwillingness or inability to cooperate in the study
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Singapore General Hospital
Singapore, Singapore, 169608
Not Yet Recruiting
2
Duke NUS Medical School
Singapore, Singapore, 169857
Actively Recruiting
3
Changi General Hospital
Singapore, Singapore, 529889
Actively Recruiting
4
Sengkang General Hospital
Singapore, Singapore, 544886
Not Yet Recruiting
Research Team
T
Tzy Tiing Lim
CONTACT
M
Marton Adriana, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here