Actively Recruiting
TITAN Trial: Reducing Phantom Limb Pain in People with Amputations
Led by Neuroscience Research Australia · Updated on 2024-12-05
208
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to investigate the effectiveness of two rehabilitation programs for individuals who have undergone amputations and are experiencing phantom limb pain. The main question it aims to answer is: \- In individuals who have undergone amputations and are experiencing phantom limb pain, what is the effectiveness of a progressive rehabilitation program compared to a treatment program consisting of transcutaneous electrical nerve stimulation and cranial electrical stimulation on reducing pain intensity and pain interference? A total of 208 participants will be randomized into two groups: progressive rehabilitation program and stimulation devices. The progressive rehabilitation program includes pain science education, sensory training, and left/right judgements, imagined movements and mirror therapy. The treatment program for the group receiving the stimulation devices includes transcutaneous electrical nerve stimulation and cranial electrical stimulation. Both interventions will be delivered via eight, up to 1-hour telehealth sessions. Outcome measures will be assessed at baseline and weeks 12, 24 and 52.
CONDITIONS
Official Title
TITAN Trial: Reducing Phantom Limb Pain in People with Amputations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Experiencing phantom limb pain for at least three months
- Had at least one episode of phantom limb pain in the previous week
- Reported at least 4 points on pain intensity in the past 7 days using an 11-point scale
- Resident in Australia during the intervention and follow-up period
- Have access to the internet and a smart device like a mobile phone
- Proficient in English
You will not qualify if you...
- Have bilateral amputation
- Scheduled for major surgery during the study period
- Have pain in the intact limb
- Have vision impairment that prevents participation
- Have hearing impairment that prevents participation
- Have cognitive problems preventing participation (e.g., Alzheimer's, dementia)
- Have neurological disorders affecting movement of the intact limb (e.g., stroke, Parkinson's, Multiple Sclerosis)
- Have completed Graded Motor Imagery including left/right judgments, imagined movements, and mirror therapy
- Have contraindications for stimulation devices (e.g., pacemaker, spinal cord stimulator)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Neuroscience Research Australia
Randwick, New South Wales, Australia, 2031
Actively Recruiting
Research Team
J
James H McAuley, PhD
CONTACT
R
Rafael Z Pinto, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here