Transcranial Magnetic Stimulation to Treat Complex Regional Pain Syndrome in Adults Aged 18 to 70

What this Trial Is About

Researchers are studying the use of Transcranial Magnetic Stimulation TMS for treating Complex Regional Pain Syndrome CRPS, a chronic pain condition. This trial aims to compare the effects of active TMS treatment with a sham placebo treatment to see if TMS can reduce CRPS-related pain and other symptoms, including cognitive, emotional, and physical aspects. Participants will be closely monitored to understand the safety and duration of symptom relief. Participants will be randomly assigned to receive either active TMS to the target area or active TMS to a non-target area once daily for two days. The TMS treatment involves using the Magventure TMS stimulator to deliver intermittent theta burst followed by high-frequency stimulation. The trial includes a follow-up period lasting up to six months, during which pain levels and symptom changes are tracked to assess how long pain relief lasts after treatment. During the study, participants will have their pain levels and related symptoms measured before treatment, one week after treatment, and regularly up to six months. Researchers will evaluate changes in pain and how long pain relief lasts from the last treatment until pain returns. Safety monitoring includes following participants until their symptoms return to baseline for at least two consecutive weeks. The overall participation duration depends on individual symptom progression and follow-up requirements.

TMS for Complex Regional Pain Syndrome