Actively Recruiting
TMS-fNIRS Personalized Dosing
Led by Florida State University · Updated on 2026-03-18
60
Participants Needed
1
Research Sites
140 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The intent of this study is to establish technical feasibility in a clinical population (PTSD, with or without mild TBI) of personalized TMS-fNIRS technology. Thereby demonstrating the utility of transcranial magnetic stimulation - functional near-infrared spectroscopy (TMS-fNIRS) technology as a direct measure of frontal brain activity, potentially replacing the indirect motor threshold procedure that may lead to improper dosing of TMS. Personalized TMS-fNIRS technology will guide therapy for depression, post-traumatic stress disorder (PTSD), and/or traumatic brain injury (TBI)
CONDITIONS
Official Title
TMS-fNIRS Personalized Dosing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults ages 18-70 years
- Eligible for consideration of treatment with TMS for PTSD
- Diagnosis of PTSD based on CAPS-5
- No changes in psychotropic medication or supportive psychotherapy for 1 month prior to initial visit and able to maintain stable treatment during study
- Able to give informed written consent and comply with study procedures for the entire study duration
You will not qualify if you...
- Medical contraindication for neuromodulation (e.g., ferrous metal in head, seizure disorder, brain tumor, stroke, aneurysm, multiple sclerosis, etc.)
- Unable to have an MRI
- Active substance use disorder in last 3 months or current substance use causing significant impairment
- Dementia or cognitive disorder preventing study participation
- History or diagnosis of schizophrenia, schizoaffective disorder, delusional disorder, or other psychotic illness
- Suicidal risk that precludes safe participation
- OCD as primary disorder
- Taking medication that significantly lowers seizure threshold (e.g., tricyclic antidepressants, clozapine)
- Current, planned, or suspected pregnancy
- Unstable medical conditions that prevent safe TMS treatment
- Severe traumatic brain injury
- Prior TMS treatment or participation in TMS study
- Significant ongoing litigation or claims impacting research activities
- Non-English speakers due to need for rapid communication
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Isabelle Taylor
Tallahassee, Florida, United States, 32306
Actively Recruiting
Research Team
I
Isabelle Taylor, MA
CONTACT
K
Kevin Johnson, PhD, RN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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