Study of 532 nm DermaV Laser Treatment for Port Wine Stains Comparing Single High Fluence Pulse Versus Multiple Low Fluence Pulses for Safety, Tolerability, and Effectiveness

What this Trial Is About

Researchers are evaluating the treatment of port wine birthmarks using an FDA-approved 532 nm laser, called the DermaV laser. The study aims to understand how well the treatments are tolerated and whether there are differences in tolerability and results between using a single high energy laser pulse versus multiple low energy pulses. Participants have non-facial port wine stains covering at least 30 cm2 on their body and are adults aged 18 to 75 years. Participants will receive three monthly laser treatments on their port wine birthmarks. Within each treated birthmark, one area will be treated with the standard single high fluence high energy pulse, while four other areas will receive multiple low fluence lower energy pulses. A sixth area of the birthmark will not be treated and will serve as a control for comparison. The study focuses on comparing these different laser pulse approaches during the treatment period. During the study, participants will be monitored for improvement in the treated areas at six months. Researchers will assess the degree of improvement, participant satisfaction, and any side effects. Participants are asked to follow post-treatment care, limit sun exposure by using sunscreen daily, and attend follow-up visits for evaluation. Digital photographs of the treatment areas will be taken to document results and support study analysis.

Tolerability of 532 nm Laser Treatment of Port Wine Stains