Actively Recruiting
Tolerance in Beekeepers
Led by University Hospital Plymouth NHS Trust · Updated on 2025-04-30
120
Participants Needed
1
Research Sites
192 weeks
Total Duration
On this page
Sponsors
U
University Hospital Plymouth NHS Trust
Lead Sponsor
U
University of Plymouth
Collaborating Sponsor
AI-Summary
What this Trial Is About
Beekeepers experience multiple bee stings each year. Many of these beekeepers (25-60%) become sensitized to bee venom through the production of specific antibodies that target the bee venom. Although these antibodies are important in the triggering of an allergic reaction only a small number of sensitised beekeepers go on to have an allergic reaction with symptoms away from the site of the sting. These reactions can be severe and are known as anaphylactic reactions. The study investigates why some beekeepers develop severe allergic symptoms after bee stings while others do not. This study will explore factors in the blood that protect sensitised individuals from having anaphylactic reactions - meaning that despite being sensitised they are tolerant and do not react to subsequent stings.
CONDITIONS
Official Title
Tolerance in Beekeepers
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals naive to beekeeping (fewer than 2 previous bee stings, none in the last 24 months) with no history of anaphylaxis to stings
- Beekeepers with more than approximately 10 stings per year who have been beekeeping for more than 3 years with no history of anaphylaxis to bee venom
- Beekeepers diagnosed with anaphylaxis to bee venom in the last 12 months who are sensitised to bee venom (confirmed by positive specific IgE and positive skin test)
You will not qualify if you...
- Unable to understand the protocol or consent
- Unable to commit to follow-up visits
- Known history of mastocytosis or under investigation for suspected mastocytosis
- Undergoing desensitisation treatment to bee venom before the first visit
- Currently being treated with immunosuppressive medications
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Derriford Hospital - University Hospitals Plymouth
Plymouth, Devon, United Kingdom, PL65FP
Actively Recruiting
Research Team
J
Jane Evely
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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