Actively Recruiting
Tonic Pain and Transauricular Vagal Nerve Stimulation
Led by Aalborg University · Updated on 2026-01-08
36
Participants Needed
1
Research Sites
14 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to explore the effect of burst-taVNS (electric stimulation of the concha cymba) on tonic (capsaicin-induced skin pain) and acute (pressure pain sensitivity) experimental pain and cardioception. Primary outcomes include pain intensity. Secondary outcomes include sensory thresholds, resting heart rate (EKG), pupillary measurements and conditioned pain modulation.
CONDITIONS
Official Title
Tonic Pain and Transauricular Vagal Nerve Stimulation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy
- Speak and understand English
- Between 18 and 60 years old
You will not qualify if you...
- Pregnant and/or breastfeeding
- Regular use of cannabis, opioids, or other drugs
- Current or previous neurological, musculoskeletal, mental, or other illnesses (e.g., brain or spinal cord injuries, degenerative neurological disorders, major depression, cardiovascular disease, chronic lung disease)
- Regular use (once or more per week) of analgesic or other medications that may affect the trial (including paracetamol and NSAIDs)
- Recent history of acute pain, especially in the lower limbs
- Disrupted sleep within 24 hours before the experiment
- Contraindications to electrical stimulation (history of epilepsy, metal implants in head or jaw)
- Inability to cooperate
- Contraindications for capsaicin such as intolerance to chili or burns/wounds at application site
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Center For Neuroplasticity and Pain
Aalborg, Denmark, 9000
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
3
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