Actively Recruiting
Tonsillectomy and Immunosuppression in Caucasian Patients With High-risk IgA-nephropathy
Led by St. Petersburg State Pavlov Medical University · Updated on 2025-07-20
240
Participants Needed
2
Research Sites
769 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The open-label prospective non-randomised controlled aims to assess the efficacy of the combination of immunosupression (IST) and tonsillectomy (TE) in Caucasian patients at high risk of the IgA-nephropathy.
CONDITIONS
Official Title
Tonsillectomy and Immunosuppression in Caucasian Patients With High-risk IgA-nephropathy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Primary IgA-nephropathy patients with proteinuria greater than 1 gram and hematuria (more than 5 red blood cells per high power field)
- Primary IgA-nephropathy patients with proteinuria less than 1 gram and hematuria who have a greater than 11% probability of starting dialysis within 5 years and at least one histologic change such as mesangial proliferation, endocapillary hypercellularity, or cellular crescents
- Caucasian ethnicity
- Age between 18 and 75 years
You will not qualify if you...
- Age under 18 or over 75 years
- Estimated glomerular filtration rate (eGFR) less than or equal to 20 ml/min/1.73m2
- Mild renal lesions (M0, E0, S0, T0, C0), minor urinary findings, or proteinuria less than 1.0 gram
- Contraindications to immunosuppressive treatment or tonsillectomy
- Presence of any co-existing kidney disease
- Secondary IgA-nephropathy (such as Schoenlein-Henoch purpura or liver cirrhosis)
- Diabetes mellitus
- Any significant acute illness within 60 days before kidney biopsy, including infection, aseptic bone necrosis, myocardial infarction, or cerebrovascular stroke
- Incomplete empiric immunosuppressive treatment before kidney biopsy
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Research Institute of Nephrology (Pavlov Medical University)
Saint Petersburg, Russia, 197022
Actively Recruiting
2
St. Petersburg State Pavlov Medical University
Saint Petersburg, Russia, 197022
Actively Recruiting
Research Team
V
Vladimir Dobronravov, Professor, MD, PhD, DMedSci
CONTACT
Z
Zinaida Kochoyan, Nephrologist
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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