Time course EPI of human brain function during task activation.
P A Bandettini, E C Wong, R S Hinks...
https://pubmed.ncbi.nlm.nih.gov/1614324Actively Recruiting
Age: 18Years - 100Years
All Genders
Healthy Volunteers
ID01087281
Top-Down Attentional Control of Visual-Processing in Patients with Brain Lesions and Healthy Volunteers
Led by National Institute of Mental Health (NIMH) · Updated on 2026-06-04
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying how the brain processes visual information and pays attention, especially focusing on people with specific brain damage compared to those without. The goal is to understand how certain brain areas, like the prefrontal and parietal cortex, influence attention and visual processing. This study involves both patients with brain lesions and healthy volunteers to explore these brain functions in detail. Participants will take part in 4 to 10 visits over 1 to 2 years, each lasting about 2 hours. During these visits, they will undergo cognitive tests to evaluate thinking and memory, either on paper or by computer. Some participants will have brain scans using functional magnetic resonance imaging (fMRI) while performing decision-making tasks. Others may be randomly chosen for magnetoencephalography (MEG) to record brain activity. Eye movements may also be tracked during training and scanning. Throughout the study, participants will have medical history reviews, physical exams, and cognitive assessments. Some will receive brain imaging to observe brain activity during visual attention tasks. The main measurement is MRI brain signals during scans. The study monitors participants carefully, with visits spaced over months to years, to learn how brain regions control attention and how brain damage affects this process.
CONDITIONS
Brief Title
Top-Down Attentional Control of Visual-Processing
Who Can Participate
Age: 18Years - 100Years
All Genders
Healthy Volunteers
Eligibility Criteria
You may qualify if you...
- Age 18 years or older with at least a high school education
- Ability to provide informed consent and cooperate with study procedures
- Ability to read and write in English
- Patients with unilateral or bilateral focal lesions in specific brain areas (prefrontal, parietal, occipital, temporal cortex, or amygdala)
- At least three months post-stroke, lobectomy, or neurosurgical resection
- Healthy volunteers must be neurologically normal and in good general health
You will not qualify if you...
- Patients with neurological or psychiatric disorders not related to their brain lesion (e.g., epilepsy, schizophrenia), except seizure-free epilepsy patients after surgery
- Previous head injury
- Drug or alcohol abuse within the past 6 months
- Radiation treatment to the brain within three months before the study
- Healthy volunteers with any neurological or psychiatric disorders
- Healthy volunteers with previous head injury
- Healthy volunteers with drug or alcohol abuse within past 6 months
- Pregnant women or women of child-bearing potential who refuse pregnancy testing for MRI scans
- Contraindications to MRI scanning such as implanted devices, metal in the body, morbid obesity, or claustrophobia
- Color blindness preventing participation in color discrimination tasks
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Diagnostic Evaluation
Duration - Single session
Participants complete behavioral studies involving selective attention and perform attention tasks during functional MRI scans.
1 visit including MRI scanning and behavioral testing
Long-term Monitoring
Duration - Ongoing during study participation
Participants' brain activity and attentional performance are observed over time to compare different patient groups and healthy volunteers.
Additional visits may occur depending on study protocol
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
N
NIMH LBC Volunteer
S
Shruti A Japee, Ph.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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