Actively Recruiting
Top-Down Attentional Control of Visual-Processing
Led by National Institute of Mental Health (NIMH) · Updated on 2026-05-05
300
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Background: \- Previous studies have shown that people with certain types of brain damage may have particular problems paying attention and processing things that they see. Researchers are interested in comparing how people with brain damage and without brain damage process visual images. Objectives: \- To better understand the areas of the brain involved in paying attention to things that are seen. Eligibility: \- Individuals at least 18 years of age who either have had damage to one or both sides of specific parts of the brain (e.g., stroke, injury, certain neurosurgery procedures) or are healthy volunteers. Design: * The study involves 4 to 10 visits to the NIH Clinical Center over 1 to 2 years. Each visit will last approximately 2 hours. * Participants will be screened with a medical history and physical examination, and may have the cognitive testing described below during the same visit. * On the first visit and for at least one visit thereafter, participants will have cognitive testing to evaluate thinking and memory. These tests will be either written tests or computer-based tests. * Some participants will qualify for functional magnetic resonance imaging (fMRI) as part of the study. This part will involve a decision-making task that will be performed on a computer during the fMRI scan. Additional scans may be required as directed by the study doctors. * Some randomly selected participants will be asked to have magnetoencephalography (MEG), a procedure to record very small magnetic field changes produced by brain activity. * During the behavioral training, or fMRI or MEG scanning, participants may be monitored with equipment to track eye movements.
CONDITIONS
Official Title
Top-Down Attentional Control of Visual-Processing
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older with at least a high school education
- Able to provide informed consent and cooperate with study procedures
- Able to read and write in English
- For patients: unilateral or bilateral focal lesions of prefrontal, parietal, occipital, temporal cortex, or amygdala
- For patients: at least three months post-stroke, lobectomy, or neurosurgical resection
- For healthy volunteers: neurologically normal and in good general health
You will not qualify if you...
- For patients: neurological or psychiatric disorders unrelated to the focal lesion (e.g., epilepsy, schizophrenia)
- For patients: previous head injury
- For patients: drug or alcohol abuse or addiction within past 6 months
- For patients: radiation treatment to the brain within three months prior to the experiment
- For healthy volunteers: neurological or psychiatric disorders (e.g., epilepsy, schizophrenia)
- For healthy volunteers: previous head injury
- For healthy volunteers: drug or alcohol abuse or addiction within past 6 months
- Women who are pregnant or of child-bearing potential refusing pregnancy test are excluded from fMRI
- Contraindications to MRI including implanted devices, metal fragments, or conditions like claustrophobia or morbid obesity
- Color-blind individuals are excluded from tasks involving color discrimination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
Research Team
N
NIMH LBC Volunteer
CONTACT
S
Shruti A Japee, Ph.D.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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