Actively Recruiting
ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer
Led by Insel Gruppe AG, University Hospital Bern · Updated on 2025-09-30
170
Participants Needed
7
Research Sites
215 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to learn if total removal of the pancreas is a preferable alternative to partial removal in patients with cancer of the pancreatic head who are at high risk of pancreatic leakage. The main question it aims to answer is: Does total pancreas removal improve survival without reducing quality of life compared to partial removal? The only study specific procedures are the collection of 2 blood samples (7.5ml for each time point, preoperatively and during the hospitalisation) and the completion of the questionnaires.
CONDITIONS
Official Title
ToPanc Trial: Survival After Total Versus Partial Pancreaticoduodenectomy for Adenocarcinoma of the Pancreatic Head, Distal Cholangiocarcinoma, and Ampullary Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (age 63 18 years) scheduled for partial pancreaticoduodenectomy for suspected or confirmed resectable pancreatic ductal adenocarcinoma, distal cholangiocarcinoma, or ampullary cancer (pancreaticobiliary type)
- Pancreas anastomosis assessed as high risk for postoperative pancreatic fistula based on imaging (CT, MRI, or Endoscopic Ultrasound)
- Provided written informed consent
You will not qualify if you...
- Patients with duodenal carcinoma, ampullary cancer (intestinal type), neuroendocrine tumors, benign tumors, or chronic pancreatitis
- Medical conditions impairing understanding or judgment about the trial as judged by the investigator
- Pregnancy or positive pregnancy test for women of child-bearing potential
- Inability to follow study procedures due to psychological disorders, dementia, or similar conditions
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Department of Surgery, Kantonsspital Baden
Baden, Switzerland, 5404
Actively Recruiting
2
Department of Visceral Surgery, University Hospital Basel
Basel, Switzerland, 4031
Not Yet Recruiting
3
Inselspital, Bern University Hospital
Bern, Switzerland, 3010
Actively Recruiting
4
Department of Visceral Surgery, University Hospital Geneva
Geneva, Switzerland, 1205
Actively Recruiting
5
Department of General, Visceral, Endocrine and Transplantation Surgery, Kantonsspital St. Gallen
Sankt Gallen, Switzerland, 9000
Actively Recruiting
6
Department of Surgery, Stadtspital Triemli Zürich
Zurich, Switzerland, 8063
Not Yet Recruiting
7
Department of Surgery and Transplantation, University Hospital Zürich
Zurich, Switzerland, 8091
Actively Recruiting
Research Team
A
Anna S Wenning, MD, PhD
CONTACT
N
Nadine Uebersax
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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