Actively Recruiting
Topical Anti-Androgens in Pilonidal Sinus Disease
Led by University of Pennsylvania · Updated on 2026-02-27
75
Participants Needed
1
Research Sites
155 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this randomized clinical trial is to test the topical drug clascoterone in patients with pilonidal disease, which is a common, benign skin condition of the gluteal cleft. The main questions it aims to answer are: * Does clascoterone improve the severity of pilonidal disease as scored by a physician? * Does clascoterone improve patient symptoms due to pilonidal disease? * Does clascoterone improve the inflammation seen under the microscope in pilonidal disease removed at surgery Participants will apply clascoterone or a placebo cream to the diseased area for 3 months. They will be assessed every 4 weeks for disease severity assessed by a physician viewing patient photos and a symptom-based survey. Researchers will compare participants who received clascoterone treatment to those who received placebo.
CONDITIONS
Official Title
Topical Anti-Androgens in Pilonidal Sinus Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 and above
- Diagnosis of Pilonidal Disease
- Willingness to comply with study procedures and availability for duration of study
- Ability to apply topical medications and willing to adhere to regimen
You will not qualify if you...
- Current use of any topical medication to natal cleft
- Presence of pilonidal-associated abscess
- Pregnancy or lactation
- Allergic reaction to components of 1% clascoterone cream
- Febrile illness within 7 days
- Treatment with another investigational drug within three months
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19103
Actively Recruiting
Research Team
L
Lillias Maguire, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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