Evaluating Lactobacillus Reuteri and Minoxidil for Treating Androgenetic Alopecia in Adults Aged 18 to 60

What this Trial Is About

Researchers are evaluating the safety and effectiveness of applying Lactobacillus reuteri topically to treat androgenetic alopecia, a common form of hair loss. This randomized, double-blind, placebo-controlled trial aims to determine whether balancing the scalps microbial community can support hair follicle function. The study compares the probiotic solution to inactivated probiotic, saline placebo, and 5% minoxidil over one year. Participants will be randomly assigned to one of four groups active Lactobacillus reuteri powder dissolved in saline, inactivated Lactobacillus reuteri powder in saline, 5% minoxidil solution, or saline placebo. Each treatment is applied once daily to the scalp using cotton swabs after cleansing, with participants avoiding hair washing for at least 6 hours afterward. The treatment period lasts 12 months. During the study, participants will have follow-up visits at 1, 3, 6, and 12 months to assess hair density and hair thickness. Assessments include scalp evaluation and hair measurements. The trial monitors safety and treatment adherence throughout. The main outcome is the change in hair count per square centimeter after one year, with additional measures of hair quality to help understand the potential benefits of these treatments.

Topical Application of Lactobacillus Reuteri for Androgenetic Alopecia