Actively Recruiting
Topical Diclofenac for Prevention of Radiation-induced Dermatitis
Led by The Second Affiliated Hospital of Hainan Medical University · Updated on 2026-04-03
156
Participants Needed
1
Research Sites
80 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Radiation induced dermatitis (RID) is one of the leading adverse events of radiation therapy, and if occurred could alter the course of therapy. The main pathways of RID is inflammation and oxidative stress on local and systemic bases. The Diclofenac is a COX-2 inhibitor and Nonsteroidal anti-inflammatory drugs whose anti-inflammatory and antioxidant activities have been proven in several clinical trials. Thus, the aim of the present study is to evaluate the efficacy of Diclofenac sodium gel as a prophylactic method against the development of RID.
CONDITIONS
Official Title
Topical Diclofenac for Prevention of Radiation-induced Dermatitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female aged 18 years or older
- Performance status less than 2
- Diagnosed with epithelial carcinoma of oropharynx, nasopharynx, larynx, hypopharynx, paranasal sinus, salivary glands, or breast cancer
- Planned to receive at least 50 Gy total radiation dose
- Radiation dermatitis rating of 0 and good skin nutrition at baseline
- Normal functioning of main organs with blood and biochemical tests meeting specified thresholds
- Willing and able to provide signed informed consent and comply with study procedures
You will not qualify if you...
- Pregnant or breastfeeding women
- Known allergy or intolerance to any study product components
- Severe heart or lung diseases such as unstable angina, significant heart failure, recent heart attack, or severe lung conditions
- Active inflammatory skin diseases like atopic dermatitis, contact dermatitis, psoriasis, lichen planus, or pityriasis rosea
- Systemic diseases that delay skin healing, such as diabetes or severe kidney failure
- Skin damage caused by malignant tumors
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The Second Affiliated Hospital of Hainan Medical University
Haikou, Hainan, China, 570311
Actively Recruiting
Research Team
Y
yuecan zeng
CONTACT
J
junnv xu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here