Actively Recruiting
Topical 5-Fluorouracil Effervescent Powder in the Treatment of Vitiligo
Led by Al-Azhar University · Updated on 2026-01-06
60
Participants Needed
1
Research Sites
167 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
A novel approach for 5-Fluorouracil delivery based on a solid effervescent formulation is proposed . 5-Fluorouracil is water soluble (\~50mg/ml) and therefore has been used for the development of novel topical formulations including nano and microparticles intended for skin targeting. After hydration 5-Fluorouracil could form a complex, a suspension or even be formulated to generate effervescence. In effervescent technology, gas bubbles occur from the liquid after chemical reaction between alkali salts and organic acids (mainly citric or tartaric. Due to liberation in CO2 gas, the dissolution of drug in water is enhanced. The aim of this study is the development and clinical evaluation of topical 5-florouracil effervescent powder formulation in the treatment of vitiligo.
CONDITIONS
Official Title
Topical 5-Fluorouracil Effervescent Powder in the Treatment of Vitiligo
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with localized stable vitiligo
- Age older than 10 years
- Vitiligo lesions stable for at least 1 year
- No vitiligo treatment received in the 6 weeks before starting the study
- Agreed to join the study, signed written consent, and committed to follow-up
You will not qualify if you...
- Vitiligo patches on mucous membranes
- Presence of Koebner phenomenon
- Uncontrolled systemic illnesses
- Currently receiving systemic or topical treatment for vitiligo
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Facualty of Pharmacy, Al Azhar University
Cairo, Egypt, 11765
Actively Recruiting
Research Team
N
Neveen A. Kohaf, Ph.D
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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