Actively Recruiting
Topical Infliximab in Eyes With Penetrating Keratoplasty
Led by Centre hospitalier de l'Université de Montréal (CHUM) · Updated on 2026-04-27
50
Participants Needed
1
Research Sites
304 weeks
Total Duration
On this page
Sponsors
C
Centre hospitalier de l'Université de Montréal (CHUM)
Lead Sponsor
F
Fonds de recherche en ophtalmologie de l'Université de Montréal
Collaborating Sponsor
AI-Summary
What this Trial Is About
Penetrating keratoplasty is a cornea surgery involving several inflammatory complications, of which the most important is glaucoma. Researchers wish to determine whether it is safe to administer infliximab (an anti-inflammatory drug) eye drops after surgery, and whether this eye drop could prevent the occurrence of glaucoma.
CONDITIONS
Official Title
Topical Infliximab in Eyes With Penetrating Keratoplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 80 years
- First corneal transplant surgery
- Able to provide informed consent
- Able to administer eye medication or have a caregiver who can administer it
You will not qualify if you...
- Active ocular infection
- Previous corneal transplant of any type
- Advanced glaucoma or macular disease
- Active or latent systemic infections like tuberculosis, histoplasmosis, coccidioidomycosis, cytomegalovirus, pneumocystis, aspergillosis, or hepatitis B
- Cancer diagnosed within the past 5 years
- Demyelinating disease
- History or current diabetes mellitus or heart failure (NYHA class III or IV)
- Pregnancy or breastfeeding
- Allergy to infliximab or its topical formulation ingredients
- Significant abnormalities in blood count or liver enzymes
- Current or past use of anti-TNF-alpha or other anti-inflammatory biologic medications
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Centre Hospitalier de l'Université de Montréal
Montreal, Quebec, Canada, H2X 3E4
Actively Recruiting
Research Team
Z
Zobelle Tchouaga
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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