Actively Recruiting
Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis
Led by University of Illinois at Chicago · Updated on 2025-10-23
60
Participants Needed
1
Research Sites
77 weeks
Total Duration
On this page
Sponsors
U
University of Illinois at Chicago
Lead Sponsor
C
Cures Within Reach
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this randomized study will be to determine whether topical probiotic sinus irrigations are more effective compared to saline sinus irrigation controls in the treatment of active CRS in patients who have had prior sinus surgery based on subjective and objective outcome measures.
CONDITIONS
Official Title
Topical Probiotic Sinus Irrigations for Treating Chronic Sinusitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients 18 years of age or older
- Diagnosis of acute worsening of chronic rhinosinusitis with at least one symptom such as nasal obstruction, nasal discharge, facial pain or pressure, or reduced sense of smell
- Previous functional endoscopic sinus surgery performed more than 12 months before enrollment with patent sinuses suitable for the study
- Willingness to follow all study procedures for the study duration
- Understanding of the study purpose and procedures with willingness to sign informed consent
- All adult men and women with active chronic rhinosinusitis considered regardless of race, gender, or socioeconomic status
You will not qualify if you...
- Currently using topical antibiotic sinus irrigations and unwilling to stop
- Unable to complete self-administered questionnaires due to cognitive impairment, language barrier, or severe medical conditions
- Having a terminal illness, immunocompromised state, systemic disease affecting the sinuses, or recent head/sinonasal trauma that increases infection risk
- Severe or emergency complications from chronic rhinosinusitis or presence of a sinus tumor
- Pregnant or breastfeeding female patients
- Use of oral corticosteroids or oral antibiotics within the previous 2 weeks
- Presence of upper respiratory infection symptoms such as fever, chills, sneezing, runny nose, sore throat, or cough at the time of enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Illinois Hospitals & Health Sciences System
Chicago, Illinois, United States, 60612
Actively Recruiting
Research Team
V
Victoria Lee, MD
CONTACT
A
Anthony I Dick, MBBS, MPH
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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