Actively Recruiting
Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation
Led by University Health Network, Toronto · Updated on 2026-05-04
90
Participants Needed
1
Research Sites
120 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people undergoing surgery for a wrist fracture compared to not using topical TXA (placebo).
CONDITIONS
Official Title
Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients undergoing open reduction internal fixation (volar approach) for distal radius fracture surgery
- Age 18 years or older
- Able to provide informed consent
- Cognitive ability and English language skills to complete outcome measures
You will not qualify if you...
- Revision surgery or additional operations on the same wrist
- Distal radius fracture treated with dorsal surgical approach
- History of lymphedema or lymph node removal in the affected arm
- Known chronic pain conditions such as fibromyalgia or polymyalgia rheumatica
- Current or chronic use of opioids
- Known allergy to tranexamic acid
- Anticoagulant medications not stopped according to guidelines
- Previous thrombotic stroke or blood clotting disorders
- Current pregnancy or breastfeeding
- Previous neurologic injury causing paralysis of the affected shoulder or arm
- Severe heart or lung disease (ASA Grade IV or higher)
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Toronto Western Hospital
Toronto, Ontario, Canada
Actively Recruiting
Research Team
R
Ryan Paul
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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