Actively Recruiting
Topographical Distribution of Itch and Pain Receptors
Led by Aalborg University · Updated on 2025-10-01
30
Participants Needed
1
Research Sites
171 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The experiment consists of three experimental sessions conducted on three consecutive days. In all experimental sessions, the participant will fill in a series of questionnaires about how you perceive itch and pain, and about some traits of your personality, such as depression, anxiety and stress. In the first session, we will mark six test areas in your face (three on each side on jaw, cheek, and temple, respectively). Thent a series of measure-ments in each test area will be conducted:measurement of the blood flow in the skin and sensitivity tests to pressure, pinprick and stroke with a brush. In the second session, histamine will be applied in one side of the face. On the other side, cowhage spicules will be applied. After 10 minutes, all the tests will be conducted again. The third session will be identical to the second. However, instead of histamine and spicules, patches containing capsaicin will be applied. In the other side, we will apply patches with placebo (i.e., a non-active patch). After 20 minutes all the tests will be conducted again.
CONDITIONS
Official Title
Topographical Distribution of Itch and Pain Receptors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy men and women
- Age between 18 and 60 years
- Speak and understand English
You will not qualify if you...
- Pregnancy or lactation
- Drug addiction including cannabis, opioids, or other drugs
- History of neurological, immunological, musculoskeletal, cardiac, or psychiatric disorders affecting results
- Moles, wounds, scars, or tattoos in treatment or test areas
- Current use of medications affecting the trial such as antihistamines and pain killers
- Skin diseases
- Alcohol or painkiller use within 24 hours before and during study days
- Acute or chronic pain and itch
- Participation in other trials within 1 week before study entry (4 weeks for pharmaceutical studies)
- Contraindications to capsaicin including intolerance to chili or burns/wounds at application sites
- Inability to cooperate with study requirements
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Aalborg University
Gistrup, Aalborg, Denmark, 9260
Actively Recruiting
Research Team
S
Silvia Lo Vecchio
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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