Actively Recruiting
Total Knee Arthroplasty in Varus Deformity
Led by I.M. Sechenov First Moscow State Medical University · Updated on 2026-03-12
300
Participants Needed
1
Research Sites
156 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
For the first time, a comparative analysis of the limb axis in patients with unilateral knee OA will be conducted compared to the contralateral uninjured side using Multisliced computed tomography (MSCT) and vertical CT (weight-bearing CT). This analysis will identify the pathological and physiological degrees of varus in patients with unilateral gonarthrosis. Indications for mechanical and kinematic limb axis alignment will be substantiated depending on the degree of varus deformity. Aim of the study: To improve the results of total knee arthroplasty in patients with varus deformity by optimizing the degree of varus correction. Objectives: To analyze physiological and pathological varus in patients with unilateral osteoarthritis under physiological loading. To develop an algorithm for applying various types of limb alignment.
CONDITIONS
Official Title
Total Knee Arthroplasty in Varus Deformity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients over 18 years of age with grade 3-4 knee osteoarthritis and pain score of 5 or higher on a 10-point VAS scale
- Varus deformity of the lower limb with HKA angle less than 177° or varus greater than 3°
- Anesthesia risk according to ASA scale no more than III
- Body mass index less than 35 kg/m2
- Patient must be monitored throughout the 12-month study period
- Patient must be mentally competent and compliant
- Patient must provide written informed consent to participate in the study
You will not qualify if you...
- Body mass index greater than 40 kg/m2
- Instability of collateral ligaments requiring ligament installation or presence of severe bone defects
- Impaired weight-bearing ability of the opposite limb
- Presence of metal implants or foreign bodies in the lower extremities
- Previous knee surgeries such as ligament reconstruction or corrective osteotomies of femur and tibia
- Patient refusal to participate in the study
- Patient failure to comply with physician recommendations or prescribed regimen
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University clinical hospital №1 I.M.Sechenov First Moscow State Medical University. The Department of Traumatology, Orthopedics and Disaster Surgery
Moscow, Russia, 119991
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
DIAGNOSTIC
Number of Arms
2
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