Actively Recruiting
Total Neoadjuvant Treatment of Rectal Cancer by MRI-guided Radiotherapy
Led by Universitair Ziekenhuis Brussel · Updated on 2024-12-04
35
Participants Needed
1
Research Sites
291 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The TNTRect trial is a prospective observational study that will evaluate the outcome of MR-guided stereotactic body radiotherapy (SBRT) with a simultaneous integrated boost in a hypofractionated treatment of rectum cancer. Patients will be treated in 5 daily fractions of 5 Gy within an overall treatment time (OTT) of 5 days. A simultaneous integrated boost (SIB) till 30Gy will be delivered to the gross tumor volume. Patients will be treated with daily adaptive radiotherapy and online tumor gating on the MRIdian system (ViewRay Inc.). The aim of the study is to improve the complete clinical response rate to offer more patients an organ preserving approach. The primary endpoint is patient response to the treatment, assessed by endoscopy and MRI, or by medical pathology reports after potential resection was performed. As secondary endpoints local control, disease-free survival, overall survival and the patient's quality of life \& hospital anxiety and depression will be measured.
CONDITIONS
Official Title
Total Neoadjuvant Treatment of Rectal Cancer by MRI-guided Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Locally advanced rectal cancer
You will not qualify if you...
- Patients with unresectable metastatic disease at diagnosis
- Patients with an ECOG performance status > 2
- Patients not deemed fit for radiotherapy, chemotherapy or surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
UZ Brussel - Dienst Radiotherapie
Jette, Brussels Capital, Belgium, 1090
Actively Recruiting
Research Team
M
Mark De Ridder, MD
CONTACT
S
Sven Van Laere, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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