Actively Recruiting

Phase Not Applicable
Age: 18Years - 80Years
All Genders
ID06075004

Comparison of Total Periarticular Anesthetic Infiltration Versus Posterior Periarticular Infiltration Plus Low-Volume Pericapsular Nerve Group Block for Pain Control in Total Hip Replacement Surgery

Led by University of Chile · Updated on 2025-01-17

74

Participants Needed

1

Research Sites

105 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating pain management techniques for patients undergoing total hip replacement surgery due to hip osteoarthritis. This trial compares two methods of local anesthetic delivery: a total periarticular local anesthetic infiltration (PAI) versus a combination of posterior periarticular infiltration plus a low-volume ultrasound-guided pericapsular nerve group block (PENGB). The goal is to find a method that preserves muscle strength while providing effective pain relief during the first 24 hours after surgery. During surgery, patients receive either the full dose of anesthetic (60 mL of 0.25% bupivacaine with epinephrine and ketorolac) infiltrated around the joint or a partial dose (45 mL total, with 15 mL to the posterior periarticular area and 30 mL to fascia, subcutaneous tissue, and skin) combined with a 10 mL ultrasound-guided nerve block using 0.5% bupivacaine and epinephrine. All patients receive spinal anesthesia with bupivacaine and fentanyl, along with additional medications including tranexamic acid, ketoprofen, acetaminophen, and morphine administered via patient-controlled analgesia. Participants will be closely monitored from surgery through recovery and the first postoperative day. Assessments include measuring muscle strength at 3 hours after arrival to the post-anesthesia care unit to detect quadriceps motor weakness. Pain control, medication use, and side effects will also be evaluated. Outcome assessors blinded to treatment groups will perform measurements to ensure unbiased results. The total participation includes the surgery day and postoperative care during hospitalization.

CONDITIONS

Official Title

Total Periarticular Infiltration Vs Posterior Periarticular Infiltration Plus PENG Block for Hip Analgesia

Who Can Participate

Age: 18Years - 80Years
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • American Society of Anesthesiologists classification 1-3
  • Body mass index between 20 and 35 (kg/m2)
Not Eligible

You will not qualify if you...

  • Adults who are unable to give their own consent
  • Pre-existing neuropathy (assessed by history and physical examination)
  • Coagulopathy (assessed by history, physical examination, and possibly blood tests)
  • Renal failure (assessed by history, physical examination, and possibly blood tests)
  • Hepatic failure (assessed by history, physical examination, and possibly blood tests)
  • Allergy to local anesthetics or morphine
  • Pregnancy
  • Prior surgery in the inguinal area on the surgical side
  • Chronic pain syndromes requiring opioid use at home

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Trial Site Locations

Total: 1 location

1

Hospital Clínico Universidad de Chile

Santiago, Santiago Metropolitan, Chile, 8380456

Actively Recruiting

Loading map...

Research Team

D

Daniela Bravo, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

DOUBLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

TREATMENT

Number of Arms

2

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Published Research Related To This Trial

Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations.

Thomas W Wainwright, Mike Gill, David A McDonald...

https://pubmed.ncbi.nlm.nih.gov/31663402

Local infiltration analgesia or femoral nerve block for postoperative pain management in patients undergoing total hip arthroplasty. A randomized, double-blind study.

Ján Kuchálik, Anders Magnuson, Anders Lundin...

https://pubmed.ncbi.nlm.nih.gov/28850408

Randomized clinical trial comparing pericapsular nerve group (PENG) block and periarticular local anesthetic infiltration for total hip arthroplasty.

Daniela Bravo, Julián Aliste, Sebastián Layera...

https://pubmed.ncbi.nlm.nih.gov/36948525

Cadaveric study investigating the femoral nerve-sparing volume for pericapsular nerve group (PENG) block.

Prangmalee Leurcharusmee, Perada Kantakam, Pittayarat Intasuwan...

https://pubmed.ncbi.nlm.nih.gov/37028817