Effect of Preoperative Vitamin D3 Supplementation on Postoperative Hypocalcemia in Patients Undergoing Total Thyroidectomy

What this Trial Is About

Researchers are evaluating the effect of giving vitamin D3 before surgery on low calcium levels after total thyroidectomy. This prospective study focuses on patients undergoing total thyroid removal, a common surgery that can lead to temporary low calcium in the blood. The study aims to clarify if vitamin D deficiency before surgery increases the risk of low calcium after thyroidectomy, especially in cases involving thyroid cancer and central neck dissection. Participants are randomly assigned to one of two groups. One group receives vitamin D3 cholecalciferol added to fruit juice during a preoperative visit about two months before surgery. The other group receives only fruit juice without vitamin D. The study is double-blinded, meaning neither patients nor researchers know who receives vitamin D or placebo. During the study, patients are monitored for calcium levels and parathyroid activity at various times before surgery, shortly after surgery, and up to 15 days post-surgery, with additional follow-up at three months. The main outcome measured is the occurrence of low calcium 15 days after surgery. Researchers also compare the severity of low calcium, vitamin D levels, and effects in different risk groups. The total participation period includes preoperative supplementation and postoperative follow-up until three months after surgery.

Total Post-thyroidectomy Hypocalcemia After Preoperative Cholecalciferol Supplementation