Actively Recruiting
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
Led by Yale University · Updated on 2025-06-05
35
Participants Needed
1
Research Sites
576 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institute of Mental Health (NIMH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
Auditory hallucinations are among the most distressing aspects of psychotic illness, and between 10 and 30% of people with hallucinations do not respond to antipsychotic medications. The authors have used computational modeling of behavior to link brain activity to development of auditory hallucinations in the hope of guiding new treatment development. The proposed studies take the first step toward individualized treatment approaches to hallucinations by attempting causal, pharmacological manipulation of relevant model parameters underlying these phenomena.
CONDITIONS
Official Title
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-65
- English speaking
- Right handedness
- Diagnosed with schizophrenia, schizoaffective, schizophreniform, schizotypal, or brief psychotic disorder
- History of auditory verbal hallucinations occurring at least weekly
You will not qualify if you...
- Current substance dependence or active use as determined by drug test
- Any neurological, medical or developmental problem that significantly impairs cognition
- Contraindications for MRI including metallic implants, pacemakers, history of accidents with metal, or claustrophobia
- History of seizures
- History of violence
- History of suicide
- Pregnancy confirmed by urine test
- Concurrent participation in another intervention study
- History of urinary retention
- History of delirium
- Current use of cholinergic or anticholinergic medication
- History of asthma, diabetes, or cardiovascular disease
- Evidence of cardiovascular disease on EKG
- Use of dopamine-2 antagonists for less than 6 months to limit risk of extrapyramidal symptoms
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Connecticut Mental Health Center
New Haven, Connecticut, United States, 06519
Actively Recruiting
Research Team
A
Albert Powers, MD, PhD
CONTACT
S
Silmilly Toribio
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here