Actively Recruiting
Towards Optimal Treatment for High Risk Prostate Cancer
Led by Haaglanden Medical Centre · Updated on 2024-09-19
207
Participants Needed
1
Research Sites
467 weeks
Total Duration
On this page
Sponsors
H
Haaglanden Medical Centre
Lead Sponsor
T
Tata Memorial Centre
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to combine several optimized treatments of high risk prostate cancer. The main question to answer is: is it safe to combine these optimized treatments. * patients will be irradiated on the prostate and (elective) lymph nodes more concentrated but with fewer hospital visits (hypofractionation) * the tumor will get a higher dose * androgen deprivation therapy will be reduced as much al possible preventing side effects Researchers will compare oncological outcome and toxicity.
CONDITIONS
Official Title
Towards Optimal Treatment for High Risk Prostate Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men aged 18 years or older diagnosed within 6 months with high risk prostate cancer
- High risk defined as T3 based on digital rectal exam and/or Grade 4 or higher and/or PSA of 20 ug/L or higher
- Indicated for elective lymph node irradiation based on guidelines or N1 on imaging with up to 4 suspected lymph nodes
You will not qualify if you...
- Prior pelvic radiotherapy
- TransUrethral Resection of the Prostate (TURP) less than 3 months ago
- Previous prostatectomy or other primary prostate cancer treatments such as HIFU or cryotherapy
- Contraindications to MRI
- No visible lesion on prostate MRI for boost
- No PSMA-PET scan performed
- Inflammatory bowel disease
- Metastatic disease (M1)
- PSA greater than 50
- Unsuitable for stereotactic body radiotherapy or whole pelvic radiotherapy
- History of cancer other than basal cell carcinoma of the skin
AI-Screening
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Trial Site Locations
Total: 1 location
1
Haaglanden Medical Centre
Leidschendam, South Holland, Netherlands, 2262 BA
Actively Recruiting
Research Team
U
Ursula J Fisscher, PhD
CONTACT
M
Mirjam E Mast, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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