Patterns and Predictors of Chemotherapy-Induced Peripheral Neuropathy in Children with Acute Lymphoblastic Leukemia Undergoing Vincristine Treatment

What this Trial Is About

This research aims to study the patterns and predictors of chemotherapy-induced peripheral neuropathy CIPN in children aged 8 to 17 years with acute lymphoblastic leukemia ALL. The study uses a prospective longitudinal design to observe how CIPN develops over the course of chemotherapy treatment involving vincristine. Researchers also collect baseline data on patients demographics, clinical characteristics, physical symptoms, nutrition status, psychological distress, sleep quality, physical activity, social support, and coping strategies to identify factors linked to different CIPN trajectories. Participants will be assessed at multiple time points one week after each of the first four vincristine doses, and then at two-week intervals following the fourth dose, up to seven total assessments. During these visits, children will complete questionnaires covering chemotherapy-induced peripheral neuropathy, physical symptoms, nutrition, psychological distress, sleep quality, physical activity, perceived social support, and coping strategies. This approach allows detailed tracking of symptom changes and potential influencing factors throughout chemotherapy. Children involved in the study will undergo regular evaluations using the Pediatric Chemotherapy-Induced Peripheral Neuropathy P-CIN scale at specified intervals after vincristine administration. The study also gathers comprehensive information through various scales and questionnaires to monitor the childs condition and well-being. Participation requires written assent from the child and consent from their parents, and the study is planned to run until January 2026, providing a thorough observation of neuropathy development during treatment.

Tracjectories and Predictors of Chemotherapy Induced Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia