Actively Recruiting
Tracjectories and Predictors of Chemotherapy Induced Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia
Led by The Hong Kong Polytechnic University · Updated on 2026-01-08
173
Participants Needed
3
Research Sites
31 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to explore the trajectory patterns of chemotherapy induced peripheral neuropathy over the course of chemotherapy and identify predictors of distinct trajectories in children with acute lymphoblastic leukemia. A perspective longitudinal study design is utilized. Chemotherapy induced peripheral neuropathy was assessed at one week after the first use of Vincristine (VCR) (T1), one week after the second use of VCR (T2), one week after the third use of VCR (T3), one week after the fourth use of VCR (T4), two weeks after T4 (T5), two weeks after T5 (T6), two weeks after T5 (T7). Patients' demographic and clinical characteristics, physical symptoms, nutrition status, psychological distress, sleep quality, physical activity, perceived social support and coping strategy are obtained at baseline.
CONDITIONS
Official Title
Tracjectories and Predictors of Chemotherapy Induced Peripheral Neuropathy in Children With Acute Lymphoblastic Leukemia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with acute lymphoblastic leukemia
- Aged from 8 to 17 years
- Will receive Vincristine according to the Chinese Children's Cancer Group Acute Lymphoblastic Leukemia-2020 Project (CCCG-ALL-2020)
- Conscious with sufficient cognitive abilities to understand and express their physical state and psychological feelings accurately
- Written informed assent is obtained from the children and their parents for participation
You will not qualify if you...
- Participating in other experimental trials such as electrical stimulation or exercise therapy for chemotherapy-induced peripheral neuropathy symptoms
- Having severe complications including significant heart, brain, or lung function failure
- Having peripheral neuropathy symptoms caused by other diseases like genetic diseases or spinal cord injury
- Having neuromuscular diseases such as traumatic brain injury or cerebral palsy
- Having central nervous system cancer or secondary cancer
- Having multiple treatments including radiotherapy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 3 locations
1
The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital,
Zhengzhou, Henan, China
Actively Recruiting
2
Shanghai Children's Medical Center
Shanghai, China
Actively Recruiting
3
Shenzhen Children's Hospital
Shenzhen, China
Actively Recruiting
Research Team
K
Ka Yan Ho, PhD
CONTACT
T
Ting MAO
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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