Recovery Following a Prolonged Period of Intensified Exercise Training: Evaluating the Impact of Levagen+® on Alleviating Physical, Physiological and Psychological Stress

What this Trial Is About

Researchers are studying the effects of Levagen+® Palmitoylethanolamide (PEA), a dietary supplement, on recovery in healthy, trained endurance cyclists during a period of intensified cycling training. The study aims to assess how Levagen+® impacts physical, physiological, and psychological stress during and after one week of increased training load. This trial follows a randomized, double-blind, crossover design to compare the supplement against a placebo. Participants will take either 350 mg of Levagen+® (containing at least 300 mg PEA) or a placebo capsule daily for 45 days. After completing the first supplementation period, a washout phase of at least four weeks occurs before switching to the other treatment. The study includes cycling tests, such as a Functional Threshold Power test at home and endurance 40 km time trials at the research facility on Days 0, 35, 43, and 45. Between Visits 2 and 3, participants increase their average training load by 50% for seven days to simulate intensified training. During the study, participants will follow their regular training routines and record details. Researchers will collect blood samples and administer questionnaires assessing muscle soreness, exertion, arousal, sleep quality, and mood. Measurements of exercise performance, fatigue, inflammatory and oxidative stress markers, and mood changes will be taken at specified visits and daily during the intensified training and recovery phase. Safety and gastrointestinal symptoms will also be monitored throughout. The total study duration for each participant includes supplementation, washout, and crossover phases.

Training Health Recovery and Improvement Via Levagen+® Evaluation