Recovery Outcomes After Intravenous Propofol Versus Inhaled Volatile Anesthesia in Adults Undergoing Elective Non-Cardiac Surgery

What this Trial Is About

Researchers are conducting a large randomized trial with 13,000 patients to compare two types of general anesthesia techniques intravenous propofol total intravenous anesthesia TIVA and inhaled volatile general anesthesia INVA. The study focuses on patients undergoing major inpatient, minor inpatient, or outpatient surgeries lasting at least 60 minutes. It aims to identify which anesthesia method leads to better patient recovery experiences and to assess whether TIVA increases the risk of intraoperative awareness compared to INVA. Participants will be randomly assigned to receive either propofol TIVA without inhaled agents or inhaled volatile anesthesia during their surgery. Both techniques require general anesthesia with airway management using a tracheal tube or laryngeal mask airway. The trial includes various surgical categories, and patients will be monitored throughout their perioperative period to evaluate recovery outcomes and safety. During the study, patients recovery quality will be measured using the Patient Reported Quality of Recovery-15 QOR15 score on postoperative days 0, 1, 2, and 7, depending on the surgery type. Additional assessments include incidence of intraoperative awareness, delirium, functional status, health-related quality of life, patient satisfaction, and other safety outcomes up to one year after surgery. The trials follow-up extends through postoperative day 365 to comprehensively assess recovery and complications.

Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial