Actively Recruiting
Led by Washington University School of Medicine · Updated on 2025-08-05
13000
Participants Needed
20
Research Sites
52 weeks
Total Duration
W
Washington University School of Medicine
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
Researchers are conducting a large randomized trial with 13,000 patients to compare two types of general anesthesia techniques: intravenous propofol total intravenous anesthesia (TIVA) and inhaled volatile general anesthesia (INVA). The study focuses on patients undergoing major inpatient, minor inpatient, or outpatient surgeries lasting at least 60 minutes. It aims to identify which anesthesia method leads to better patient recovery experiences and to assess whether TIVA increases the risk of intraoperative awareness compared to INVA. Participants will be randomly assigned to receive either propofol TIVA without inhaled agents or inhaled volatile anesthesia during their surgery. Both techniques require general anesthesia with airway management using a tracheal tube or laryngeal mask airway. The trial includes various surgical categories, and patients will be monitored throughout their perioperative period to evaluate recovery outcomes and safety. During the study, patients' recovery quality will be measured using the Patient Reported Quality of Recovery-15 (QOR15) score on postoperative days 0, 1, 2, and 7, depending on the surgery type. Additional assessments include incidence of intraoperative awareness, delirium, functional status, health-related quality of life, patient satisfaction, and other safety outcomes up to one year after surgery. The trial's follow-up extends through postoperative day 365 to comprehensively assess recovery and complications.
CONDITIONS
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
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Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of surgery (at least 60 minutes)
Participants receive either intravenous propofol anesthesia or inhaled volatile anesthesia during their elective non-cardiac surgery.
1 surgery day visit
Duration - Up to 365 days after surgery
Participants are monitored for recovery and assessed for quality of recovery, delirium, functional status, and other health outcomes after surgery.
Multiple visits including postoperative days 0, 1, 2, 7, 30, 90, 180, and 365
Total: 20 locations
1
University of Arkansas for Medical Sciences (UAMS)
Little Rock, Arkansas, United States, 72205
Actively Recruiting
2
University of California San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
3
Stanford University
Stanford, California, United States, 94305
Not Yet Recruiting
4
Yale School of Medicine
New Haven, Connecticut, United States, 06510
Actively Recruiting
5
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
6
Brigham & Women's
Boston, Massachusetts, United States, 02115
Actively Recruiting
7
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
8
Henry Ford Health
Detroit, Michigan, United States, 48202
Actively Recruiting
9
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
10
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
11
NYU Langone
New York, New York, United States, 10012
Actively Recruiting
12
Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
13
Duke University
Durham, North Carolina, United States, 27708
Actively Recruiting
14
Wake Forest
Winston-Salem, North Carolina, United States, 27109
Actively Recruiting
15
Oregon Health and Sciences University
Portland, Oregon, United States, 97239
Actively Recruiting
16
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Not Yet Recruiting
17
University of Texas - MD Anderson
Houston, Texas, United States, 77030
Actively Recruiting
18
University of Utah - Medical
Salt Lake City, Utah, United States, 84132
Actively Recruiting
19
UVA Health
Charlottesville, Virginia, United States, 22908
Actively Recruiting
20
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
L
Laura Swisher
S
Sherry McKinnon
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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Bethany R Tellor Pennington, Allison M Janda, Douglas A Colquhoun...
https://pubmed.ncbi.nlm.nih.gov/40953862