Actively Recruiting
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Led by Washington University School of Medicine · Updated on 2025-08-05
13000
Participants Needed
20
Research Sites
254 weeks
Total Duration
On this page
Sponsors
W
Washington University School of Medicine
Lead Sponsor
P
Patient-Centered Outcomes Research Institute
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators will conduct a 13,000-patient randomized multi-center trial to determine (i) which general anesthesia technique yields superior patient recovery experiences in any of three surgical categories ((a) major inpatient surgery, (b) minor inpatient surgery, (c) outpatient surgery) and (ii) whether TIVA confers no more than a small (0.2 %) increased risk of intraoperative awareness than INVA in patients undergoing both outpatient and inpatient surgeries
CONDITIONS
Official Title
Trajectories of Recovery After Intravenous Propofol Versus Inhaled VolatilE Anesthesia Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 years or older
- Undergoing elective non-cardiac surgery expected to last �3e= 60 minutes
- General anesthesia with a tracheal tube, laryngeal mask airway, or similar device is planned
You will not qualify if you...
- Unable to provide informed consent in English or Spanish (where available)
- Pregnancy based on patient report or positive test on day of surgery
- General, regional, or neuraxial anesthesia administered within 30 days before or planned within 30 days after surgery
- Contraindication to propofol TIVA or inhaled volatile anesthesia (e.g., allergy, severe nausea, malignant hyperthermia)
- Surgical procedures requiring a specific anesthesia technique (e.g., TIVA required for neuromonitoring)
- Locally approved written protocol mandating a particular anesthesia technique
- History of possible or definite intraoperative awareness during general anesthesia
- Planned postoperative intubation
- Current incarceration
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 20 locations
1
University of Arkansas for Medical Sciences (UAMS)
Little Rock, Arkansas, United States, 72205
Actively Recruiting
2
University of California San Francisco
San Francisco, California, United States, 94143
Actively Recruiting
3
Stanford University
Stanford, California, United States, 94305
Not Yet Recruiting
4
Yale School of Medicine
New Haven, Connecticut, United States, 06510
Actively Recruiting
5
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
6
Brigham & Women's
Boston, Massachusetts, United States, 02115
Actively Recruiting
7
University of Michigan
Ann Arbor, Michigan, United States, 48109
Actively Recruiting
8
Henry Ford Health
Detroit, Michigan, United States, 48202
Actively Recruiting
9
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
10
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire, United States, 03756
Actively Recruiting
11
NYU Langone
New York, New York, United States, 10012
Actively Recruiting
12
Weill Cornell Medicine
New York, New York, United States, 10065
Actively Recruiting
13
Duke University
Durham, North Carolina, United States, 27708
Actively Recruiting
14
Wake Forest
Winston-Salem, North Carolina, United States, 27109
Actively Recruiting
15
Oregon Health and Sciences University
Portland, Oregon, United States, 97239
Actively Recruiting
16
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Not Yet Recruiting
17
University of Texas - MD Anderson
Houston, Texas, United States, 77030
Actively Recruiting
18
University of Utah - Medical
Salt Lake City, Utah, United States, 84132
Actively Recruiting
19
UVA Health
Charlottesville, Virginia, United States, 22908
Actively Recruiting
20
University of Washington
Seattle, Washington, United States, 98195
Actively Recruiting
Research Team
L
Laura Swisher
CONTACT
S
Sherry McKinnon
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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