Actively Recruiting
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Led by Radboud University Medical Center · Updated on 2023-03-31
100
Participants Needed
1
Research Sites
467 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Observational prospective pilot study to analyze the trajectory of neuroinflammatory protein expression in cerebrospinal fluid (CSF) in relation to systemic compartment in patients undergoing thoracic aortic surgery. The aim of this study is to identify and unravel the biochemical (neuroinflammatory) pathways involved in postoperative delirium. Patient undergoing thoracic aortic surgery will have an external lumbar drain (ELD) in situ on the day before surgery. This ELD remains in place during and three days after surgery to reduce the risk on periprocedural spinal cord ischemia. Paired measurements of CSF and blood will be analyzed.
CONDITIONS
Official Title
Trajectory of Neuroinflammatory Markers in Cerebrospinal Fluid Prior to and After Thoracic Aortic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Competent patients 18 years or older
- Patients undergoing thoracic aortic surgery who will receive an external lumbar drain as standard care
You will not qualify if you...
- Meningitis, encephalitis, or brain abscess within the last 6 months
- Neurological conditions including brain injury (stroke, trauma, or hemorrhage) within the last 3 months
- Known brain tumors, neurodegenerative disease, or pre-existing cognitive impairment compatible with mild cognitive impairment or worse
- Brain or spinal surgery within the last 3 months
- Active infection less than 2 weeks before surgery
- Objection to storage of body material for scientific reasons
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Intensive Care Medicine, Radboud university medical center
Nijmegen, Netherlands, 6500HB
Actively Recruiting
Research Team
W
Wilson F. Abdo, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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