Actively Recruiting

Phase 4
Age: 18Years +
All Genders
ID05345613

Usage of Tranexamic Acid During Colonic Endoscopic Resection Procedures for Reduction of Intraprocedural and Postprocedural Bleeding

Led by Assaf-Harofeh Medical Center · Updated on 2026-01-13

200

Participants Needed

1

Research Sites

4 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are evaluating the use of tranexamic acid (TXA) to prevent bleeding during and after endoscopic mucosal resection (EMR) of large colon polyps. EMR is a technique to remove superficial growths in the colon but can cause significant bleeding during and after the procedure. This study aims to compare the effects of local TXA injection versus standard treatment including adrenaline, focusing on reducing bleeding complications. Participants will be randomly assigned to receive either a submucosal injection of a standard solution containing TXA or a standard solution that includes adrenaline during the EMR procedure. The study is single-blinded and includes two groups: the TXA group and the standard therapy group. The trial evaluates bleeding rates during the procedure and within two weeks afterward to assess safety and effectiveness. During the study, participants will undergo the EMR procedure with assigned injections and be monitored for bleeding events both during and up to two weeks after the procedure. Researchers will collect data on intraprocedural and postprocedural bleeding, treatment side effects, and other relevant outcomes. The study involves follow-up visits to assess bleeding and recovery, and participation may last for a few weeks following the procedure.

CONDITIONS

Brief Title

Tranexamic Acid During Colonic Endoscopic Resection Procedures

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients referred for endoscopic resection of non-neoplastic and neoplastic lesions in the colon presenting to the tertiary academic center
  • Age greater than 18 years
Not Eligible

You will not qualify if you...

  • History of allergic reactions to tranexamic acid (TXA)
  • History of seizures
  • Pregnancy

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
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Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Treatment

Duration - Day of the procedure

Participants undergo the endoscopic resection procedure with submucosal injection of either tranexamic acid or standard solution including adrenaline as part of the study intervention.

1 procedure visit (in-person)

Follow-up

Duration - Up to 2 weeks after the procedure

Participants are monitored for postprocedural bleeding and other outcomes following the endoscopic resection procedure.

Approximately 1 to 2 follow-up visits (in-person)

Trial Site Locations

Total: 1 location

1

Shamir Medical Center

Be’er Ya‘aqov, Israel, 70300

Actively Recruiting

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Research Team

A

Anton Bermont, MD

S

Sergei Vosko, MD

How is the study designed?

Study Type

INTERVENTIONAL

Masking

SINGLE

Allocation

RANDOMIZED

Model

PARALLEL

Primary Purpose

PREVENTION

Number of Arms

2

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Published Research Related To This Trial

Snare tip soft coagulation achieves effective and safe endoscopic hemostasis during wide-field endoscopic resection of large colonic lesions (with videos).

Farzan Fahrtash-Bahin, Bronte A Holt, Vanoo Jayasekeran...

https://pubmed.ncbi.nlm.nih.gov/23570622

Prophylactic endoscopic coagulation to prevent delayed post-EMR bleeding in the colorectum: a prospective randomized controlled trial (with videos).

Hyun Seok Lee, Seong Woo Jeon, Yong Hwan Kwon...

https://pubmed.ncbi.nlm.nih.gov/31175874

Prophylactic clip closure reduced the risk of delayed postpolypectomy hemorrhage: experience in 277 clipped large sessile or flat colorectal lesions and 247 control lesions.

Hammad Liaquat, Elizabeth Rohn, Douglas K Rex

https://pubmed.ncbi.nlm.nih.gov/23317580

Impact of including epinephrine in the submucosal injectate for colorectal EMR on postprocedural pain: a randomized controlled trial.

Douglas K Rex, Rachel E Lahr, Merritt M Peterson...

https://pubmed.ncbi.nlm.nih.gov/34896443