Actively Recruiting
Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis
Led by Vanderbilt University Medical Center · Updated on 2026-05-07
60
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will be a prospective randomized study to evaluate the effect of tranexamic acid (TXA) use on intraoperative and postoperative outcomes among patients undergoing rhinoplasty by two Facial Plastic surgeons at Vanderbilt. Outcomes will include intra- and post-operative bleeding and postoperative bruising and swelling.
CONDITIONS
Official Title
Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults at least 18 years of age who elect to undergo cosmetic or functional open primary rhinoplasty with osteotomies by Drs. Yang or Patel at VUMC
- No other facial plastic or sinus surgery performed at the same time
- Must not meet any of the exclusion criteria
You will not qualify if you...
- Known allergy to tranexamic acid (TXA)
- Intracranial bleeding
- Known defective color vision
- History of venous or arterial thromboembolism
- Active thromboembolic disease
- Severe renal impairment (chronic kidney disease)
- History of coagulation disorder
- Known thrombocytopenia (platelets less than 150,000)
- Current use of anticoagulant medication
- Uncontrolled diabetes mellitus preventing use of dexamethasone perioperatively
- Cardiac arrhythmia
- History of acute myocardial infarction, stroke, seizure, or liver failure
- Laboratory values showing platelets less than 150,000, prothrombin time greater than 45, INR greater than 1.2, or seizure disorder
AI-Screening
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Trial Site Locations
Total: 1 location
1
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
Actively Recruiting
Research Team
S
Shiayin F Yang, MD
CONTACT
J
Jaclyn Lee, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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