Actively Recruiting
TRANS-FOODS: Preventing Peanut Allergy Through Improved Understanding of the Transcutaneous Sensitisation Route, Novel Food Processing and Skin Care Adaptations
Led by King's College London · Updated on 2024-05-06
120
Participants Needed
1
Research Sites
60 weeks
Total Duration
On this page
Sponsors
K
King's College London
Lead Sponsor
U
University Hospital, Bonn
Collaborating Sponsor
AI-Summary
What this Trial Is About
This project aims to study the immune responses to peanut allergen in those with a skin barrier defect with and without skin massage, specifically it aims to: 1. Establish if peanut allergen components can pass into human skin through regular massage using the peanut protein-containing extract. 2. Clarify whether this effect is amplified in those with an impaired skin barrier (AD and dry skin vs healthy controls). 3. Assess whether peanut protein components can be detected in interstitial skin fluid (ISF) using a suction device. 4. Test whether peanut protein components present in ISF are able to induce activation of basophils in blood of peanut allergic donors. 5. Assess whether the transcutaneous uptake of peanut protein can be reduced by the prior use of a barrier enhancing cream.
CONDITIONS
Official Title
TRANS-FOODS: Preventing Peanut Allergy Through Improved Understanding of the Transcutaneous Sensitisation Route, Novel Food Processing and Skin Care Adaptations
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult healthy volunteers or adults with dry skin or atopic dermatitis (AD) meeting specific criteria, making up 50% each of the study group
- Willingness to apply study treatments and avoid other topical products on forearms during the study
You will not qualify if you...
- History of peanut allergy
- Positive skin prick test to peanut (greater than 0 mm)
- Do not regularly consume peanut products
- Have widespread atopic dermatitis, especially on the forearms where testing occurs
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Unit for Population-Based Dermatology Research
London, United Kingdom, SE1 7EH
Actively Recruiting
Research Team
S
Stuart Jones
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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