Actively Recruiting
Led by M.D. Anderson Cancer Center · Updated on 2026-02-04
20
Participants Needed
4
Research Sites
N/A
Total Duration
This research aims to compare the symptoms and appetite levels of patients who have undergone minimally-invasive proximal gastrectomy (MIPG) versus those who have undergone minimally-invasive total gastrectomy (MITG) for proximal gastric and gastroesophageal junction cancers. The study seeks to determine if MIPG is linked to better postoperative appetite, improved nutritional status, and maintained body weight compared to MITG. It also investigates patient-reported outcomes, safety, and oncological results related to both surgeries. Participants will complete questionnaires within 30 days before surgery and then at 1, 3, 6, and 12 months after surgery. These questionnaires focus on health, appetite, and quality of life and take about 3 to 5 minutes to finish. The study measures fasting ghrelin levels to explore their relationship with appetite and collects data on symptoms using the MD Anderson Symptom Inventory Gastrointestinal Cancer Module (MDASI-GI). During the study, patients will be assessed repeatedly through questionnaires to track changes in symptoms and quality of life over a year following surgery. The main outcome is the symptom inventory questionnaire completed three months after surgery. Researchers will also look into factors affecting quality of life after surgery and monitor safety and cancer outcomes. This observational study includes adults aged 18 and older with specific types of gastric cancer and continues until May 2026.
CONDITIONS
Trans-Pacific Multicenter Collaborative Study of Minimally Invasive Proximal Versus Total Gastrectomy for Proximal Gastric and Gastroesophageal Junction Cancers
You may qualify if you...
You will not qualify if you...
Complete this quick 3-step screening to check your eligibility
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person) to confirm eligibility
Duration - Surgery day and immediate recovery period
Participants undergo minimally-invasive proximal gastrectomy (MIPG) or minimally-invasive total gastrectomy (MITG) as part of their treatment.
1 day of surgery and hospital stay as per routine care
Duration - Up to 12 months after surgery
Participants complete questionnaires about health, appetite, and quality of life before surgery and at multiple timepoints after surgery to assess recovery and nutritional status.
Questionnaires at 1, 3, 6, and 12 months after surgery plus 1 baseline questionnaire within 30 days before surgery
Total: 4 locations
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Active, Not Recruiting
2
M D Anderson Cancer Center
Houston, Texas, United States, 77030
Actively Recruiting
3
Keio University School of Medicine
Tokyo, Japan, 1600016
Actively Recruiting
4
Yonsei University College of Medicine
Soeul, South Korea, 03722
Actively Recruiting
N
Naruhiko Ikoma, MD
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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Naruhiko Ikoma, Travis Grotz, Hirofumi Kawakubo...
https://pubmed.ncbi.nlm.nih.gov/41023216Naruhiko Ikoma, Travis Grotz, Hirofumi Kawakubo...
https://pubmed.ncbi.nlm.nih.gov/37653380