Study of Transarterial Microembolization for Moderate Knee Osteoarthritis with Inflammatory Symptoms in Adults Over 40

What this Trial Is About

Knee osteoarthritis OA is a common degenerative and inflammatory joint disease causing pain and limited mobility, affecting millions worldwide. This research evaluates the clinical results of treating patients with knee OA and chronic pain that has not improved after at least three months of conventional conservative therapy. The study focuses on selective arterial embolization as a treatment option for patients who are not candidates for or refuse surgery and suffer from refractory chronic pain. The treatment involves transarterial microembolization, which selectively targets and blocks blood vessels causing inflammation in the knee. This procedure uses micro-catheters to inject embolizing material into pathological genicular arterial branches, followed by diagnostic arteriography to confirm successful embolization. The study includes 43 patients who will undergo this procedure after providing informed consent. Patients will be followed up with clinical evaluations at 1, 3, 6, 12, and 24 months after treatment or until they drop out for other reasons. Participants will be involved in regular clinical assessments to monitor pain levels using the Visual Analog Scale VAS and other measures like quality of life SF-36, joint function WOMAC score, range of motion, and overall treatment assessment over two years. Researchers will also measure bilateral knee circumferences to evaluate changes. The study aims to understand the treatments impact on pain reduction and joint function over time, with ongoing safety and progress monitoring throughout the follow-up period.

"Transarterial Microembolization (TAME) in Inflammatory Knee Pathology"