Actively Recruiting
"Transarterial Microembolization (TAME) in Inflammatory Knee Pathology"
Led by Istituto Ortopedico Rizzoli · Updated on 2026-04-07
43
Participants Needed
1
Research Sites
313 weeks
Total Duration
On this page
Sponsors
I
Istituto Ortopedico Rizzoli
Lead Sponsor
O
Ospedale San Giuseppe Moscati, Avellino
Collaborating Sponsor
AI-Summary
What this Trial Is About
Patients with knee OA and chronic pain refractory to at least 3 months of conventional conservative therapy will be included in the study, which will evaluate the clinical results obtained after treatment with selective arterial embolization (selection and enrollment, treatment with selective arterial embolization, follow-up checks). Forty-three patients will be included in the study and will undergo the transarterial microembolization procedure after signing the informed consent form for participation in the study and the collection of anamnestic data. Subsequently, patients will be followed up with clinical evaluation at 1, 3, 6, 12, and 24 months of follow-up or until possible dropout for other treatment.
CONDITIONS
Official Title
"Transarterial Microembolization (TAME) in Inflammatory Knee Pathology"
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with degenerative knee disease
- Age over 40 years
- Moderate knee osteoarthritis (grade 2-3) with indication for total knee arthroplasty
- Knee osteoarthritis with inflammatory symptoms such as night pain, pain at rest, swelling, or redness
- Persistent moderate or severe knee pain with VAS score greater than 4
- Failure of at least 3 months of conservative treatments including physical therapy, NSAIDs, injections, or orthobiologics
- Signed informed consent form
- Eligibility confirmed by internal multidisciplinary discussion on degenerative-inflammatory disease
You will not qualify if you...
- Mentally incompetent patients
- Trauma to the knee within 6 months before treatment
- Malignant tumors
- Rheumatic diseases
- Use of anticoagulant or anti-platelet therapy (even if discontinued 5 days prior)
- Abuse of alcohol, drugs, or medications
- Knee surgery within the previous 12 months
- INR less than 2
- Platelet count below 30,000
- Renal failure with GFR below 30 ml/min
- Pregnancy
- Allergy to iodinated contrast agents
- Unable to undergo MRI examination
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
IRCCS Istituto Ortopedico Rizzoli
Bologna, Bologna, Italy, 40136
Actively Recruiting
Research Team
G
Giancarlo Facchini, Medicine and Surgery
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here