Study of Transcranial Alternating Current Stimulation to Improve Thinking Skills in Lewy Body Dementia

What this Trial Is About

Researchers are studying the safety, feasibility, and effects of transcranial alternating current stimulation tACS in people with Lewy Body Dementia DLB. This study aims to understand how tACS, a non-invasive brain stimulation method using mild electrical currents, influences brain activity and cognitive functions like memory and perception in DLB patients. The trial is double-blind, randomized, and placebo-controlled to compare real tACS with placebo treatment. Participants will be randomly assigned to one of two groups one group will receive real tACS sessions and the other will receive sham placebo tACS sessions. Both groups will undergo 10 sessions over two weeks, with five sessions per week, each lasting about 60 minutes. The sham group will receive brief stimulation that stops after a few seconds, mimicking the real procedure without ongoing electrical current. During the study, participants will visit at the start, after two weeks, and again at 12 weeks for follow-up. At each visit, they will undergo blood tests, clinical and neuropsychological assessments, EEG and TMS-EEG brain recordings. Researchers will monitor for any adverse events throughout the study and analyze biological markers to understand disease mechanisms and treatment effects. The primary outcomes include safety, feasibility, and changes in cognitive tests over 12 weeks.

Transcranial Alternating Current Stimulation in Lewy Body Dementia