Actively Recruiting
Can Transcranial Doppler Predict Postoperative Cognitive Dysfunction After Cardiopulmonary Bypass
Led by Bakirkoy Dr. Sadi Konuk Research and Training Hospital · Updated on 2026-02-17
106
Participants Needed
1
Research Sites
4 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures. Variations in cerebral blood flow and oxygen extraction are considered key contributing factors. Although pulsatile flow during bypass has shown benefits for renal function and recovery, its effects on postoperative neurological dysfunction and delirium remain unclear due to limited research. This study aims to evaluate the impact of pulsatile versus non-pulsatile cardiopulmonary bypass flow on POCD in adult CABG patients by measuring middle cerebral artery (MCA) flow using transcranial Doppler.
CONDITIONS
Brief Title
Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-70
- Patients scheduled for isolated elective cardiopulmonary bypass surgery
You will not qualify if you...
- Patients with carotid stenosis ≥50%
- Emergency patients or those with a history of reoperation
- Patients with a history of cerebrovascular events
- Patients who do not provide consent
- Patients with temporal window failure
- Patients with an ejection fraction (EF) <40%
- Patients with a Mini-Mental State Examination (MMSE) score <23
- Patients who require mechanical ventilation for more than 24 hours or those who are reintubated
AI-Screening
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Trial Site Locations
Total: 1 location
1
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
S
Sema Nur Baki, M.D
D
Dicle Birtane, M.D, FCCM
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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