Actively Recruiting
Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass
Led by Bakirkoy Dr. Sadi Konuk Research and Training Hospital · Updated on 2026-02-17
106
Participants Needed
1
Research Sites
54 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Neurological dysfunction either transient or permanent is a major cause of morbidity and mortality after cardiopulmonary bypass, and cognitive dysfunction is more frequent in cardiac surgery than in non-cardiac procedures. Variations in cerebral blood flow and oxygen extraction are considered key contributing factors. Although pulsatile flow during bypass has shown benefits for renal function and recovery, its effects on postoperative neurological dysfunction and delirium remain unclear due to limited research. This study aims to evaluate the impact of pulsatile versus non-pulsatile cardiopulmonary bypass flow on POCD in adult CABG patients by measuring middle cerebral artery (MCA) flow using transcranial Doppler.
CONDITIONS
Official Title
Transcranial Doppler as a Predictor of Postoperative Cognitive Dysfunction Following Cardiopulmonary Bypass
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients aged 18-70
- Scheduled for isolated elective cardiopulmonary bypass surgery
You will not qualify if you...
- Carotid stenosis 50% or greater
- Emergency patients or those with a history of reoperation
- History of cerebrovascular events
- Patients who do not provide consent
- Temporal window failure
- Ejection fraction below 40%
- Mini-Mental State Examination score below 23
- Mechanical ventilation for more than 24 hours or reintubation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Istanbul, Turkey (Türkiye)
Actively Recruiting
Research Team
S
Sema Nur Baki, M.D
CONTACT
D
Dicle Birtane, M.D, FCCM
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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