Actively Recruiting
Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating Diseases
Led by Xuanwu Hospital, Beijing · Updated on 2025-07-01
80
Participants Needed
1
Research Sites
117 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Non-invasive neurostimulation can effectively improve patients' symptoms and has shown good therapeutic efficacy in alleviating the symptoms of IIDDs (Inflammatory Immune-mediated Demyelinating Diseases). However, some patients have not achieved the desired results, which may be due to individual differences in neural responsiveness . Therefore, this study aims to assess the therapeutic effect of transcranial electrical stimulation on improving symptoms such as painful spasm in IIDDs patients, by considering both the overall characteristics of IIDDs disease symptoms and individual differences in patients. The study will explore the imaging characteristics, electrophysiological features of the disease symptoms, and their relationship with clinical manifestations, while analyzing the key factors that influence treatment efficacy.
CONDITIONS
Official Title
Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating Diseases
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients diagnosed with neuromyelitis optica spectrum disorder, multiple sclerosis, or other central nervous system inflammatory demyelinating diseases that meet the diagnostic criteria
- Numeric Rating Scale (NRS) pain score 4
- Age between 18 and 65 years, regardless of gender
- Stable dose of immunosuppressive therapy for at least one month
- EDSS score 6
- Right-handed
- Agree to participate and sign the informed consent form
You will not qualify if you...
- A history of relapse within the past month
- Recent medication adjustments or treatment with modified electroconvulsive therapy, transcranial magnetic stimulation, or other neurostimulation techniques within the past month
- Participation in any other clinical trial within the past month or currently participating in another clinical trial
- Presence of cochlear implants, pacemakers, or implanted stimulators in the brain
- Skin integrity at the electrode placement site is compromised, or allergy to electrode gel or adhesive
- A history of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections
- Pregnant or breastfeeding women, or those planning to become pregnant in the near future
- A score of 3 on item 3 (suicide item) of the HDRS-17, or a history of severe psychiatric disorders
- Presence of severe or unstable organic diseases
- Poor patient compliance preventing cooperation with treatment, follow-up, or clinical, EEG, and imaging data collection
- Any other situation deemed unsuitable for participation in the study by the investigator
AI-Screening
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Trial Site Locations
Total: 1 location
1
Xuanwu Hospital, Capital Medical University
Beijing, China
Actively Recruiting
Research Team
J
Junwei Hao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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