Actively Recruiting
Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants
Led by University of Nottingham · Updated on 2025-09-29
20
Participants Needed
1
Research Sites
45 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study examines the impact of theta-burst transcranial focused ultrasound stimulation (tFUS) on cognitive performance in healthy participants, specifically focusing on both acute and post-stimulation effects on visual working memory (vWM). The investigation will compare TUS effects across targeted deep cortical and subcortical brain regions involved in cognitive processing. Neurophysiological changes following stimulation will be assessed using EEG, providing insight into tFUS-induced modulations in working memory-related brain activity.
CONDITIONS
Official Title
Transcranial Focused Ultrasound Stimulation to Enhance Cognition in Healthy Participants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 55 years
- Healthy adults with no history of neurological or psychiatric disorders
- Eligible to undergo a T1-weighted MRI scan for neuronavigation
- Ability to follow the study schedule and complete all assessments
- Right-handed
- Fluent in English
- No use of recreational drugs in the 48 hours before participation
- No consumption of more than 4 alcoholic units in the 24 hours before participation
You will not qualify if you...
- Any current psychiatric diagnosis
- Neurodevelopmental disorders or history of central nervous system disease, concussion, or neurological issues
- Presence of brain tumors, seizures, meningitis, encephalitis, or abnormal MRI brain findings
- Use of psychotropic medications within five half-lives before the procedure
- Metal implants contraindicated for MRI
- History of head trauma with loss of consciousness
- Calcification in brain areas targeted by ultrasound
- Visual impairments that cannot be corrected with glasses
- Inability to complete cognitive testing
- Participation in other clinical trials affecting psychosocial function
- History of repeated substance abuse or dependence except nicotine and caffeine
- Use of stimulants, modafinil, thyroid medication, or steroids
- Skin disease on or near the scalp
- History of seizure or epilepsy or use of medications lowering seizure threshold
- Claustrophobia or conditions preventing MRI
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Neuromodulation Lab, Medical School, Queen's Medical Centre
Nottingham, Nottinghamshire, United Kingdom, NG7 2UH
Actively Recruiting
Research Team
S
Stefanos A Kontogouris, PhD Student
CONTACT
M
Mohammad Alkhawashki, PhD Student
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
BASIC_SCIENCE
Number of Arms
4
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