Actively Recruiting
Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
Led by University of Pennsylvania · Updated on 2026-03-05
24
Participants Needed
1
Research Sites
80 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
T
Temple University
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with Speech-Language Therapy (SLT) is an effective treatment for mild aphasia in persons with chronic stroke. The main questions this study aims to answer are: 1. Can TMS combined with SLT improve conversational speech and comprehension? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and SLT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat post-stroke mild aphasia. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo a MRI * Participate in 10 consecutive sessions (Monday-Friday) of TMS and SLT treatment * Complete follow-up assessments 2 and 4 months after treatment
CONDITIONS
Official Title
Transcranial Magnetic Stimulation + Language Therapy to Treat Mild Aphasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Left Hemisphere stroke
- Stroke occurred more than 6 months ago
- Mild Aphasia (WAB AQ score > 85)
- Proficient in English
You will not qualify if you...
- Ongoing substance or alcohol abuse
- Other neurological disorders besides stroke (e.g., dementia, traumatic brain injury, multiple sclerosis)
- Active psychiatric disorders (e.g., bipolar disorder, schizophrenia)
- Pacemaker or cardiac defibrillator
- Diagnosis of tinnitus
- Epilepsy or seizure in the past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19014
Actively Recruiting
Research Team
H
Harris Drachman, MS
CONTACT
D
Daniela Sacchetti, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here