Actively Recruiting
Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
Led by University of Pennsylvania · Updated on 2026-04-29
63
Participants Needed
1
Research Sites
225 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke. The main questions this study aims to answer are: 1. Can TMS combined with mCILT improve overall speech? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment? Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia. Importantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting. Participants will: * Complete a screening and medical intake to determine eligibility * Undergo MRI scans * Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment * Complete follow-up assessments immediately and 4 months after treatment
CONDITIONS
Official Title
Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Left hemisphere stroke resulting in aphasia
- Stroke occurred between 2 and 6 weeks before enrollment
- Able to understand the study and provide informed consent
- Proficient in English
- Right-handed
You will not qualify if you...
- History of serious or ongoing substance abuse
- Previous head trauma with loss of consciousness over 5 minutes
- History of major psychiatric illness
- Dementia or other neurological conditions
- Epilepsy or seizure after the stroke
- Presence of a pacemaker
- Diagnosis of tinnitus
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19014
Actively Recruiting
Research Team
L
Leslie Vnenchak, MA, CCC-SLP
CONTACT
D
Daniela Sacchetti, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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