Actively Recruiting
Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy
Led by Oregon Health and Science University · Updated on 2025-05-29
30
Participants Needed
1
Research Sites
378 weeks
Total Duration
On this page
Sponsors
O
Oregon Health and Science University
Lead Sponsor
N
National Center of Neuromodulation for Rehabilitation
Collaborating Sponsor
AI-Summary
What this Trial Is About
The objective of this proposal is to investigate the effect of non-invasive repetitive cerebellar transcranial magnetic stimulation (rTMS) on motor control in progressive supranuclear (PSP). The central hypothesis is that augmenting cerebellar inhibition via cerebellar rTMS will decrease postural instability in patients with PSP. We will use functional near infrared spectroscopy (fNIRS) to examine changes in motor and premotor cortical activity after cerebellar rTMS.
CONDITIONS
Official Title
Transcranial Magnetic Stimulation in Progressive Supranuclear Palsy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Probable or possible progressive supranuclear palsy (PSP) by revised MDS PSP Criteria (Hoglinger 2017)
- Age between 40 and 85 years at screening
- Ability to understand and cooperate with simple instructions in English
- Ability to read at a 6th grade reading level in English
- Ability to stand unassisted for at least 30 seconds and walk independently with a walker
- Ability to avoid starting new physical or speech therapy during the study
- Ability to remain on stable doses of any cholinergic, dopaminergic, serotonergic sedative, or NMDA receptor antagonist medications during the study
- Females of child-bearing age must have a negative urine pregnancy test and use reliable birth control during the study
You will not qualify if you...
- Other significant neurological or vestibular disorders
- Presence of electrically, magnetically, or mechanically activated implants
- History of injurious metal exposure in eyes, head, or body
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
Research Team
G
Graham Harker
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
TREATMENT
Number of Arms
2
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