Actively Recruiting
Transcranial Magnetic Stimulation Synchronized with Motor Task Training for Post-Stroke Rehabilitation
Led by First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University · Updated on 2025-02-27
15
Participants Needed
1
Research Sites
51 weeks
Total Duration
On this page
Sponsors
F
First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University
Lead Sponsor
S
shanghai center for brain science and brain-inspired technology
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trials is to investigate the effectiveness of individualized online repetitive transcranial magnetic stimulation (rTMS) in enhancing upper limb motor rehabilitation during the subacute and chronic phase of stroke. It will also learn about the safety of individualized online rTMS intervention methods. The main questions it aims to answer are: Does rTMS synchronized with motor training improve motor rehabilitation in patients with the ability to induce motor evoked potentials(MEPs)？ Dose individualized rTMS synchronized with motor training improve motor rehabilitation in patients without the ability to induce MEPs? Researchers will compare online rTMS to offline and sham stimulation in patients with MEPs to see if online rTMS works to alleviate motor dysfunction in preliminary trials. And compare individualized online rTMS to non-individualized online rTMS and sham in patients without MEPs to see if individualized online rTMS works to alleviate motor dysfunction in Randomized, double-blinded, and controlled trials. Participants will: randomized to one group acoording to the MEP condition of each person; receive rTMS treatment for 10 days, with 5 working days per week for a total of two weeks; receive magnetic resonance imaging (MRI) and electroencephalogram (EEG) evaluations before and after the entire treatment; conduct scales and MEP assessment one day before the treatment, as well as one day, one month, and three months after the treatment.
CONDITIONS
Official Title
Transcranial Magnetic Stimulation Synchronized with Motor Task Training for Post-Stroke Rehabilitation
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Diagnosed with stroke by neurological exam, CT, or MRI
- Stable vital signs with some upper limb motor dysfunction
- Age between 20 and 80 years old
- Cognitive ability sufficient to cooperate with assessments, with MMSE score ≥ 20
- No serious complications like pneumonia, heart failure, urinary infection, or malnutrition
- No medical history contraindicating TMS such as brain metal implants, pacemakers, pregnancy, or epilepsy history
- Signed informed consent by patient or guardian
You will not qualify if you...
- Severe heart, lung, liver, or kidney diseases or malignant tumors
- History of aphasia, severe cognitive impairment, or mental illness
- Epileptic seizures in the last month or recent anti-epileptic drug use
- Severe vision or hearing impairments preventing normal communication
- Metal implants, pacemakers, skull defects, or other conditions preventing TMS
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University
Shanghai, Shanghai Municipality, China, 200021
Actively Recruiting
Research Team
Y
Ying Wang
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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