Actively Recruiting
Transcranial Magnetic Stimulation (TMS) for Negative Symptoms in Schizophrenia Spectrum Disorders
Led by The University of Texas Health Science Center, Houston · Updated on 2026-03-24
20
Participants Needed
1
Research Sites
246 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to determine if repetitive transcranial magnetic stimulation (rTMS) applied to angular gyrus (AG) will improve negative symptoms and/or other psychosis symptoms in schizophrenia spectrum disorders (SSD) patients compared with prefrontal cortex (PFC) or sham.
CONDITIONS
Official Title
Transcranial Magnetic Stimulation (TMS) for Negative Symptoms in Schizophrenia Spectrum Disorders
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Ability to give written informed consent
- Diagnosed with schizophrenia-spectrum disorder and Evaluation to Sign Consent (ESC) above 10
- Currently under care of a licensed primary care or mental healthcare provider
- Negative symptoms with BNSS score of 20 or more
- Agree to provide written permission for communication between investigators and healthcare providers within two years of enrollment
You will not qualify if you...
- First-degree relative with inherited epilepsy, seizure disorder, or seizures, or positive response to epilepsy screening questionnaire
- Taking more than 400 mg clozapine per day without sufficient anti-seizure medication
- Failed TMS screening questionnaire
- Significant recent substance dependence or positive urine toxicology for substances other than nicotine or marijuana dependence
- Major medical illnesses affecting brain function (e.g., stroke, CNS infection, tumor, significant neurological conditions)
- Presence of cardiac pacemakers, implanted pumps, intracardiac lines, intracranial implants, or other metal objects near the head that cannot be safely removed
- History of head injury with loss of consciousness over 10 minutes or brain surgery
- Inability to refrain from alcohol or marijuana use 24 hours or more prior to experiments
- Pregnancy or child-bearing potential without contraception and recent unprotected intercourse
- Moderate to high risk of suicide per Columbia-Suicide Severity Rating Scale or investigator judgement
- History or family history of deep vein thrombosis
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
X
Xiaoming Du, PhD
CONTACT
K
Keiko Kunitoki
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
4
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