Actively Recruiting
Transcranial Magnetic Stimulation (TMS) to Treat Depression in Autism Spectrum Disorder
Led by Yale University · Updated on 2025-07-02
60
Participants Needed
1
Research Sites
135 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
A
American Academy of Child Adolescent Psychiatry.
Collaborating Sponsor
AI-Summary
What this Trial Is About
This study will assess clinical and behavioral measures along with electroencephalogram (EEG), event-related potentials (ERPS), and eye-tracking (ET) prior to and following a single intermittent Theta Burst Stimulation (iTBS) session to provide preliminary insight into the potential of TMS as an intervention for depression in individuals with Autism Spectrum Disorder (ASD).
CONDITIONS
Official Title
Transcranial Magnetic Stimulation (TMS) to Treat Depression in Autism Spectrum Disorder
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Individuals aged 18 to 40 years old with or without a diagnosis of depression, including those with autism spectrum disorder, autistic disorder, PDD NOS, or Asperger syndrome
- Depression score of at least 20 on the HDRS-17 scale
- Unmedicated or on stable medication for at least two weeks
- Willing and able to participate in EEG and eye-tracking procedures
- Signed and dated informed consent provided
You will not qualify if you...
- History of significant head trauma or serious brain illness
- Unable to provide signed informed consent
- Major psychiatric illness that prevents study completion, including psychotic or bipolar disorders
- History of serious medical illness, stroke, seizures, epileptiform EEG abnormalities, or family history of epilepsy
- Taking medications that affect cognitive processes or increase seizure risk
- Alcohol or recreational drug use within 24 hours before study visit
- Substance or alcohol abuse or dependence in the past 6 months
- Significant suicide risk or suicide attempt in the last 6 months, or active suicidal ideation
- Known or suspected pregnancy or positive pregnancy test
- History of metalworking injury or shrapnel/metallic object injury
- Prior TMS therapy or investigational drug use within 12 weeks before visit
- IQ below 80 as confirmed by the WASI test
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Yale Psychiatric Hospital
New Haven, Connecticut, United States, 06520
Actively Recruiting
Research Team
S
Sherab Tsheringla, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
CROSSOVER
Primary Purpose
PREVENTION
Number of Arms
8
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