Actively Recruiting
Transcranial Pulse Stimulation of the Brain
Led by University of Florida · Updated on 2026-04-29
20
Participants Needed
1
Research Sites
146 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will investigate transcranial pulse stimulation (TPS) as a method of enhancing cognitive and neural function. The study team will apply this low intensity, magnetically pulse technology to key brain regions in a randomized, sham-controlled trial (RCT). The study will determine the magnitude of changes in cognitive function and brain function and structure between a pre- and post-stimulation among 10 typically-aging older adults and 10 patients with mild dementia.
CONDITIONS
Official Title
Transcranial Pulse Stimulation of the Brain
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men and women
- Age between 65 and 84 years
- English speaking
- Physically mobile with no history of balance difficulties or major falls
- For typically-aging older adults: Telephone Interview for Cognitive Status (TICS) score of 33 or higher, Montreal Cognitive Assessment (MoCA) score of 26 or higher, and Clinical Dementia Rating (CDR) Sum of Boxes score of 0
- For mild dementia group: TICS score between 21 and 32, MoCA score less than 23, and CDR Sum of Boxes score between 4.5 and 9.0 as assessed by an informant
You will not qualify if you...
- Neurological disorders unrelated to dementia or Alzheimer's disease (e.g., Parkinson's disease, stroke, seizures, traumatic brain injury)
- Evidence of dementia or Alzheimer's disease more severe than mild (CDR Sum of Boxes score greater than 9.0 or MoCA score less than 10)
- Past opportunistic brain infection
- Major psychiatric illness including schizophrenia, severe depression, substance dependence, agitation, or delirium
- Unstable or chronic medical conditions such as cancer (other than basal cell skin cancer) or diabetes
- Contraindications for MRI (e.g., pregnancy, claustrophobia, metal implants)
- Physical impairments that prevent motor response, lying still for an hour, or walking two blocks without stopping or balance problems
- Use of medications with sedating or strong anticholinergic effects unless stable for at least four weeks
- Medical history increasing risk of cerebrovascular events, including prior heart attack or cardiac arrhythmia
- Hearing or vision problems that prevent reliable cognitive testing unless corrected to appropriate levels
- Left-handedness or ambidextrousness
- Blood clotting disorders or thrombosis
- Corticosteroid treatment in the six weeks before the first treatment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Florida
Gainesville, Florida, United States, 32610
Actively Recruiting
Research Team
J
Joseph M Gullett, Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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