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Exploring Noninvasive Temporal Interference Stimulation of CM-pf for Adults With Disorders of Consciousness and Severe Brain Injury
Led by Xijing Hospital · Updated on 2025-04-09
10
Participants Needed
2
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effect of noninvasive neuromodulation using transcranial temporal interference stimulation tTIS applied to the central medial-parafascicular CM-pf region in patients with disorders of consciousness, including those with severe brain injury, unresponsive wakefulness syndrome, and minimally conscious state. The study aims to explore how this device-based treatment may impact the recovery of consciousness in affected patients. Participants will receive tTIS treatment over the bilateral CM-pf once a day for 10 days. This intervention involves the use of a device designed to stimulate specific brain regions noninvasively, with no placebo or comparator group mentioned. The treatment period is limited to 10 consecutive days. During the study, researchers will assess changes in the Coma Recovery Scale-Revised CRS-R total score from enrollment to the end of the 10-day treatment. They will also monitor the number of patients showing improved consciousness and observe electroencephalogram EEG changes over the same period. The study includes adults aged 18 to 65 years and involves close monitoring throughout the treatment duration.
CONDITIONS
Brief Title
Transcranial Temporal Interference Stimulation In Severely Brain Injured Patients With Disorders of Consciousness
Research Team
G
Gengyao Hu
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