Actively Recruiting
TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
Led by Brigham and Women's Hospital · Updated on 2024-08-22
350
Participants Needed
1
Research Sites
874 weeks
Total Duration
On this page
Sponsors
B
Brigham and Women's Hospital
Lead Sponsor
A
American Heart Association
Collaborating Sponsor
AI-Summary
What this Trial Is About
Hypothesis: The investigators hypothesize that genetic variants will alter gene expression in response to ischemia during cardiopulmonary bypass. To test this, the investigators will be taking small pieces of heart tissue from patients undergoing heart surgery before and after this period of ischemia. This will be compared to blood gene expression in blood cells and analyzed with the patients' genetic profile. This might allow us to assess the amount of inflammation that occurs when patients are on the heart-lung machine as well as examine the effects genes have on this critical time period.
CONDITIONS
Official Title
TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged greater than 20 years
- Undergoing aortic valve surgery with or without CABG surgery
- Receive an apical vent as part of the surgery
You will not qualify if you...
- Will not receive an apical left ventricular vent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02115
Actively Recruiting
Research Team
J
Jochen D Muehlschlegel, MD, MMSc, MBA
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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