Actively Recruiting
Transcriptomic Profiling of Cumulus Cells From CAPA-IVM
Led by Mỹ Đức Hospital · Updated on 2025-11-21
10
Participants Needed
1
Research Sites
23 weeks
Total Duration
On this page
Sponsors
M
Mỹ Đức Hospital
Lead Sponsor
V
Vrije Universiteit Brussel
Collaborating Sponsor
AI-Summary
What this Trial Is About
Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic profile may serve as a non-invasive biomarker of oocyte and embryo competence. This prospective pilot study will analyze CCs gene expression after CAPA-IVM using RNA sequencing and pathway analysis, and correlate findings with embryological outcomes including fertilization, day-3 cleavage, and blastocyst formation. Results are expected to provide insights into the molecular basis of oocyte competence and support development of non-invasive embryo selection strategies.
CONDITIONS
Official Title
Transcriptomic Profiling of Cumulus Cells From CAPA-IVM
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Women 18 to 38 years old
- Body mass index (BMI) less than or equal to 32 kg/m2
- Diagnosed with polycystic ovary syndrome (PCOS) by Rotterdam 2003 criteria, meeting at least two of these: oligo-ovulation/anovulation, clinical or biochemical signs of hyperandrogenism, or polycystic ovarian morphology on ultrasound
- Eligible for CAPA-IVM treatment
- Serum anti-Mullerian hormone (AMH) level of at least 4 ng/mL
- Antral follicle count (AFC) of 24 or more follicles in both ovaries at treatment indication
- Signed informed consent to participate
You will not qualify if you...
- Sperm retrieved from surgical procedures
- Previous IVF cycle where all retrieved oocytes were immature
AI-Screening
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Trial Site Locations
Total: 1 location
1
My Duc Hospital
Ho Chi Minh City, Vietnam
Actively Recruiting
Research Team
H
Huy H Pham, MSc.
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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