Actively Recruiting
Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
Led by Centre Hospitalier Universitaire Dijon · Updated on 2026-01-29
60
Participants Needed
1
Research Sites
48 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.
CONDITIONS
Official Title
Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Person who has given written consent
- Person with systemic scleroderma (for patients)
- Person undergoing plastic, cosmetic and reconstructive surgery (for control participants)
You will not qualify if you...
- Person not affiliated to or not benefiting from a social security scheme
- Person subject to a legal protection measure (curatorship, guardianship)
- An adult who is incapable or unable to give consent
- Minors
- Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases (for control participants)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
CHU Dijon Bourgogne
Dijon, France, 21000
Actively Recruiting
Research Team
B
Bernard BONNOTTE
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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