Actively Recruiting
Transcutaneous Auricular Vagus Enhanced Recovery in the NeuroICU
Led by Washington University School of Medicine · Updated on 2025-10-21
160
Participants Needed
1
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study will demonstrate the impact of taVNS on reducing adverse events in NeuroICU patients, determine if taVNS reduces length of stay, and quantify the economic benefits of taVNS implementation in a broader neurocritical care population.
CONDITIONS
Official Title
Transcutaneous Auricular Vagus Enhanced Recovery in the NeuroICU
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Admission to the NeuroICU within 36 hours of onset of an acute medical condition
- Patient or authorized legal representative able to provide consent within 36 hours of ICU arrival
- Presence of at least one predictor of critical illness or severe brain/spinal cord injury such as:
- Glasgow Coma Scale (GCS) greater than 3 and less than or equal to 12 at admission
- NIH stroke scale of 6 or greater
- Requirement for ongoing mechanical ventilation
- Requirement for ongoing vasopressor support
- Diagnosis of subarachnoid hemorrhage
- Diagnosis of intracerebral hemorrhage with hematoma volume greater than 5 ml
- Diagnosis of moderate to severe traumatic brain injury (GCS greater than 3 and less than or equal to 12)
- Refractory status epilepticus requiring continuous sedative infusions
You will not qualify if you...
- Systemic immunosuppression
- Receiving ongoing cancer therapy
- Implanted electrical device such as pacemaker or stimulator
- Sustained bradycardia on admission with heart rate less than 50 bpm for more than 5 minutes
- Risk of imminent death or limitation of care (e.g., Glasgow Coma Scale of 3, pupillary dilatation)
- Expected ICU stay of less than 72 hours as determined by physician
- Pregnancy
- COVID-19
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
Research Team
R
Raj Dhar, MD
CONTACT
A
Anna Huguenard, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here